| Drug General Information |
| Drug ID |
D04QOU
|
| Former ID |
DNC002456
|
| Drug Name |
Adenosine-5'-Diphosphate
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C10H14N5NaO10P2
|
| Canonical SMILES |
C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)[<br />O-])O.[Na+]
|
| InChI |
1S/C10H14N5O10P2.Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20;/h2-4,6-7,10,17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20);/q-1;+1/t4-,6-,7-,10-;/m1./s1
|
| InChIKey |
LYSWXRSUQLGBIC-MCDZGGTQSA-N
|
| CAS Number |
CAS 20398-34-9
|
| PubChem Compound ID |
|
| PubChem Substance ID |
|
| Target and Pathway |
| Target(s) |
Glycogen synthase kinase-3 beta |
Target Info |
Inhibitor |
[1]
|
|---|
| 73-kDa molecular chaperone HSP73 |
Target Info |
Inhibitor |
[1]
|
| Phosphopantetheine adenylyltransferase |
Target Info |
Inhibitor |
[1]
|
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
Target Info |
Inhibitor |
[1]
|
| Aurora kinase A |
Target Info |
Inhibitor |
[1]
|
| Pyridoxal kinase |
Target Info |
Inhibitor |
[1]
|
| Mast/stem cell growth factor receptor |
Target Info |
Inhibitor |
[1]
|
| Pantothenate kinase |
Target Info |
Inhibitor |
[1]
|
| Glutamate--cysteine ligase regulatorysubunit |
Target Info |
Inhibitor |
[1]
|
| Kinesin-like protein KIF11 |
Target Info |
Inhibitor |
[1]
|
| Thymidine monophosphate kinase |
Target Info |
Inhibitor |
[1]
|
| D-alanine--D-alanine ligase |
Target Info |
Inhibitor |
[1]
|
| Heat shock protein HSP 90 |
Target Info |
Inhibitor |
[1]
|
| 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase |
Target Info |
Inhibitor |
[1]
|
| Thymidine kinase |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
|
|
Superpathway of cholesterol biosynthesis
|
|
Mevalonate pathwayPLPSAL-PWY:Pyridoxal 5'-phosphate salvage
|
|
KEGG Pathway
|
ErbB signaling pathway
|
|
Chemokine signaling pathway
|
|
Cell cycle
|
|
PI3K-Akt signaling pathway
|
|
Wnt signaling pathway
|
|
Hedgehog signaling pathway
|
|
Axon guidance
|
|
Hippo signaling pathway
|
|
Focal adhesion
|
|
Signaling pathways regulating pluripotency of stem cells
|
|
T cell receptor signaling pathway
|
|
B cell receptor signaling pathway
|
|
Neurotrophin signaling pathway
|
|
Dopaminergic synapse
|
|
Insulin signaling pathway
|
|
Melanogenesis
|
|
Prolactin signaling pathway
|
|
Thyroid hormone signaling pathway
|
|
Non-alcoholic fatty liver disease (NAFLD)
|
|
Alzheimer's disease
|
|
Hepatitis C
|
|
Measles
|
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Influenza A
|
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HTLV-I infection
|
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Epstein-Barr virus infection
|
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Pathways in cancer
|
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Colorectal cancer
|
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Endometrial cancer
|
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Prostate cancer
|
|
Basal cell carcinomahsa03040:Spliceosome
|
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MAPK signaling pathway
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Protein processing in endoplasmic reticulum
|
|
Endocytosis
|
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Antigen processing and presentation
|
|
Estrogen signaling pathway
|
|
Legionellosis
|
|
Toxoplasmosis
|
|
Epstein-Barr virus infectionhsa00770:Pantothenate and CoA biosynthesis
|
|
Metabolic pathwayshsa00900:Terpenoid backbone biosynthesis
|
|
Metabolic pathways
|
|
Biosynthesis of antibiotics
|
|
AMPK signaling pathway
|
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Bile secretionhsa04114:Oocyte meiosishsa00750:Vitamin B6 metabolism
|
|
Metabolic pathwayshsa04014:Ras signaling pathway
|
|
Rap1 signaling pathway
|
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Cytokine-cytokine receptor interaction
|
|
Hematopoietic cell lineage
|
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Acute myeloid leukemia
|
|
Central carbon metabolism in cancerhsa00480:Glutathione metabolism
|
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Metabolic pathwaysmtu00240:Pyrimidine metabolism
|
|
Metabolic pathwaysmtc00473:D-Alanine metabolism
|
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Peptidoglycan biosynthesis
|
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Metabolic pathways
|
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Vancomycin resistancehsa04141:Protein processing in endoplasmic reticulum
|
|
NOD-like receptor signaling pathway
|
|
Progesterone-mediated oocyte maturation
|
|
NetPath Pathway
|
TCR Signaling Pathway
|
|
TSH Signaling Pathway
|
|
IL4 Signaling PathwayNetPath_17:IL5 Signaling Pathway
|
|
TGF_beta_Receptor Signaling Pathway
|
|
TSH Signaling PathwayNetPath_25:FSH Signaling PathwayNetPath_15:IL3 Signaling Pathway
|
|
IL4 Signaling Pathway
|
|
KitReceptor Signaling PathwayNetPath_14:IL2 Signaling Pathway
|
|
PANTHER Pathway
|
Alzheimer disease-presenilin pathway
|
|
Angiogenesis
|
|
Cadherin signaling pathway
|
|
Hedgehog signaling pathway
|
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Insulin/IGF pathway-protein kinase B signaling cascade
|
|
Interleukin signaling pathway
|
|
PDGF signaling pathway
|
|
PI3 kinase pathway
|
|
Wnt signaling pathway
|
|
Ras Pathway
|
|
CCKR signaling map STP00006:Apoptosis signaling pathway
|
|
Parkinson diseaseP00014:Cholesterol biosynthesisP02770:Pyridoxal phosphate salvage pathway
|
|
Vitamin B6 metabolism
|
|
Pathway Interaction Database
|
LPA receptor mediated events
|
|
Degradation of beta catenin
|
|
Reelin signaling pathway
|
|
Presenilin action in Notch and Wnt signaling
|
|
Integrin-linked kinase signaling
|
|
CDC42 signaling events
|
|
LKB1 signaling events
|
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Canonical Wnt signaling pathway
|
|
Role of Calcineurin-dependent NFAT signaling in lymphocytes
|
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Glucocorticoid receptor regulatory network
|
|
C-MYC pathway
|
|
Regulation of Androgen receptor activity
|
|
BMP receptor signaling
|
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Hedgehog signaling events mediated by Gli proteins
|
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Signaling events mediated by Stem cell factor receptor (c-Kit)
|
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Validated transcriptional targets of deltaNp63 isoforms
|
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Aurora A signaling
|
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Insulin-mediated glucose transport
|
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Class I PI3K signaling events mediated by Akt
|
|
p53 pathway
|
|
Trk receptor signaling mediated by PI3K and PLC-gammasmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
|
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C-MYB transcription factor networkaurora_b_pathway:Aurora B signaling
|
|
Signaling by Aurora kinases
|
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PLK1 signaling events
|
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Aurora A signalingcmyb_pathway:C-MYB transcription factor network
|
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Signaling events mediated by Stem cell factor receptor (c-Kit)hdac_classii_pathway:Signaling events mediated by HDAC Class II
|
|
Validated targets of C-MYC transcriptional activation
|
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Regulation of Telomerase
|
|
Class I PI3K signaling events
|
|
IL2 signaling events mediated by PI3K
|
|
Integrins in angiogenesis
|
|
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
|
|
ErbB receptor signaling network
|
|
VEGFR1 specific signals
|
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Signaling events mediated by VEGFR1 and VEGFR2
|
|
PathWhiz Pathway
|
Steroid BiosynthesisPW000053:Vitamin B6 MetabolismPW000003:Glutamate Metabolism
|
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Glutathione Metabolism
|
|
Cysteine Metabolism
|
|
Reactome
|
Degradation of beta-catenin by the destruction complex
|
|
AKT phosphorylates targets in the cytosol
|
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Regulation of HSF1-mediated heat shock response
|
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CRMPs in Sema3A signaling
|
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Disassembly of the destruction complex and recruitment of AXIN to the membrane
|
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S33 mutants of beta-catenin aren't phosphorylated
|
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S37 mutants of beta-catenin aren't phosphorylated
|
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S45 mutants of beta-catenin aren't phosphorylated
|
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T41 mutants of beta-catenin aren't phosphorylated
|
|
Degradation of GLI2 by the proteasome
|
|
Constitutive Signaling by AKT1 E17K in CancerR-HSA-3371453:Regulation of HSF1-mediated heat shock response
|
|
Attenuation phase
|
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HSF1-dependent transactivation
|
|
Lysosome Vesicle Biogenesis
|
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Golgi Associated Vesicle Biogenesis
|
|
CHL1 interactions
|
|
mRNA Splicing - Major PathwayR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
|
|
Regulation of PLK1 Activity at G2/M TransitionR-HSA-1257604:PIP3 activates AKT signaling
|
|
Regulation of KIT signaling
|
|
Constitutive Signaling by Aberrant PI3K in Cancer
|
|
RAF/MAP kinase cascadeR-HSA-2132295:MHC class II antigen presentation
|
|
KinesinsR-HSA-1236382:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
|
|
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
|
|
Regulation of actin dynamics for phagocytic cup formation
|
|
eNOS activation
|
|
Regulation of PLK1 Activity at G2/M Transition
|
|
Loss of Nlp from mitotic centrosomes
|
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Recruitment of mitotic centrosome proteins and complexes
|
|
Loss of proteins required for interphase microtubule organization?from the centrosome
|
|
EPHA-mediated growth cone collapse
|
|
VEGFA-VEGFR2 Pathway
|
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VEGFR2 mediated vascular permeability
|
|
Anchoring of the basal body to the plasma membrane
|
|
Constitutive Signaling by EGFRvIII
|
|
WikiPathways
|
DNA Damage Response (only ATM dependent)
|
|
Senescence and Autophagy in Cancer
|
|
Notch Signaling Pathway
|
|
Glycogen Metabolism
|
|
Insulin Signaling
|
|
Wnt Signaling Pathway
|
|
Wnt Signaling Pathway and Pluripotency
|
|
IL-6 signaling pathway
|
|
Wnt Signaling Pathway Netpath
|
|
Copper homeostasis
|
|
Focal Adhesion
|
|
Hair Follicle Development: Induction (Part 1 of 3)
|
|
Cardiac Hypertrophic Response
|
|
Degradation of beta-catenin by the destruction complex
|
|
T-Cell Receptor and Co-stimulatory Signaling
|
|
Cardiac Progenitor Differentiation
|
|
BDNF signaling pathway
|
|
Corticotropin-releasing hormone
|
|
B Cell Receptor Signaling Pathway
|
|
IL17 signaling pathway
|
|
Neural Crest Differentiation
|
|
Alzheimers Disease
|
|
IL-7 Signaling Pathway
|
|
Regulation of Microtubule Cytoskeleton
|
|
TWEAK Signaling Pathway
|
|
Leptin signaling pathway
|
|
Semaphorin interactions
|
|
Cell Cycle
|
|
MicroRNAs in cardiomyocyte hypertrophy
|
|
Androgen receptor signaling pathway
|
|
IL-5 Signaling PathwayWP410:Diurnally Regulated Genes with Circadian Orthologs
|
|
MAPK Signaling Pathway
|
|
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
|
|
GABA synthesis, release, reuptake and degradation
|
|
Parkin-Ubiquitin Proteasomal System pathway
|
|
Membrane Trafficking
|
|
L1CAM interactionsWP1857:Metabolism of water-soluble vitamins and cofactorsWP430:Statin Pathway
|
|
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
|
|
Activation of Gene Expression by SREBP (SREBF)
|
|
SREBF and miR33 in cholesterol and lipid homeostasis
|
|
Integrated Breast Cancer Pathway
|
|
SREBP signalling
|
|
Cholesterol BiosynthesisWP437:EGF/EGFR Signaling Pathway
|
|
JAK/STAT
|
|
Gastric Cancer Network 1
|
|
APC/C-mediated degradation of cell cycle proteinsWP1857:Metabolism of water-soluble vitamins and cofactorsWP304:Kit receptor signaling pathway
|
|
Differentiation Pathway
|
|
Signaling by SCF-KIT
|
|
PIP3 activates AKT signaling
|
|
miR-targeted genes in muscle cell - TarBase
|
|
miR-targeted genes in lymphocytes - TarBase
|
|
miR-targeted genes in epithelium - TarBaseWP3:Transcriptional activation by NRF2
|
|
NRF2 pathway
|
|
Nuclear Receptors Meta-Pathway
|
|
Metabolism of amino acids and derivatives
|
|
Trans-sulfuration and one carbon metabolism
|
|
Trans-sulfuration pathway
|
|
Phase II conjugation
|
|
Glutathione metabolismWP2679:MHC class II antigen presentation
|
|
KinesinsWP2884:NRF2 pathway
|
|
Aryl Hydrocarbon Receptor Pathway
|
|
Binding and Uptake of Ligands by Scavenger Receptors
|
|
Signaling by ERBB2
|
|
Fcgamma receptor (FCGR) dependent phagocytosis
|
|
Influenza Life Cycle
|
|
EBV LMP1 signaling
|
|
Aryl Hydrocarbon Receptor
|
|
TNF alpha Signaling Pathway
|
|
Arylhydrocarbon receptor (AhR) signaling pathway
|
|
Signaling by EGFR
|
|
Mitotic G2-G2/M phases
|
|
Metabolism of nitric oxide
|
|
NOD pathway
|
| References |
| REF 1 | DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January |
|---|
