Target Information
Target General Infomation | |||||
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Target ID |
T79724
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Former ID |
TTDR00748
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Target Name |
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
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Gene Name |
folK
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Synonyms |
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; 7,8- dihydro-6-hydroxymethylpterin-pyrophosphokinase; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK; PPPK; folK
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Target Type |
Research
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BioChemical Class |
Kinase
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UniProt ID | |||||
EC Number |
EC 2.7.6.3
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Sequence |
MTVAYIAIGSNLASPLEQVNAALKALGDIPESHILTVSSFYRTPPLGPQDQPDYLNAAVA
LETSLAPEELLNHTQRIELQQGRVRKAERWGPRTLDLDIMLFGNEVINTERLTVPHYDMK NRGFMLWPLFEIAPELVFPDGEMLRQILHTRAFDKLNKW |
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Inhibitor | 6-Hydroxymethyl-7,8-Dihydropterin | Drug Info | [551393] | ||
6-Hydroxymethylpterin | Drug Info | [551391] | |||
Acetate Ion | Drug Info | [551393] | |||
Adenosine-5'-Diphosphate | Drug Info | [551391] | |||
Alpha,Beta-Methyleneadenosine-5'-Triphosphate | Drug Info | [551393] | |||
P(1)-(6-Hydroxymethylpterin)-P(2)-(5'-adenosyl)diphosphate | Drug Info | [535155] | |||
P(1)-(6-Hydroxymethylpterin)-P(4)-(5'-adenosyl)tetraphosphate | Drug Info | [535155] | |||
[Pterin-6-Yl Methanyl]-Phosphonophosphate | Drug Info | [551393] | |||
References | |||||
Ref 535155 | Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: synthesis and biochemical and crystallographic studies. J Med Chem. 2001 Apr 26;44(9):1364-71. |
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