Drug General Information
Drug ID	D0Z0JF
Former ID	DIB020301
Drug Name	M-5MPEP
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541533]
Structure		Download 2D MOL
Formula	C15H13NO
InChI	InChI=1S/C15H13NO/c1-12-6-8-14(16-11-12)9-7-13-4-3-5-15(10-13)17-2/h3-6,8,10-11H,1-2H3
InChIKey	CCQPQKFLWKYOMJ-UHFFFAOYSA-N
PubChem Compound ID	16036762
PubChem Substance ID	24419250, 26585854, 41796079, 57379642, 103584395, 178103012, 196375807, 224122822, 229925366, 246308566
Target and Pathway
Target(s)	Metabotropic glutamate receptor 5	Target Info	Modulator (allosteric modulator)	[527733]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Huntington's disease
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 541533	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6396).
Ref 527733	A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators. Mol Pharmacol. 2005 Dec;68(6):1793-802. Epub 2005 Sep 9.

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