Drug Information

Drug General Information
Drug ID
D0M2EX
Former ID
DNC000988
Drug Name
Naltrindole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539015]
Formula
C26H26N2O3
InChI
InChI=1S/C26H26N2O3/c29-19-8-7-15-11-20-26(30)12-17-16-3-1-2-4-18(16)27-22(17)24-25(26,21(15)23(19)31-24)9-10-28(20)13-14-5-6-14/h1-4,7-8,14,20,24,27,29-30H,5-6,9-13H2/t20-,24+,25+,26-/m1/s1
InChIKey
WIYUZYBFCWCCQJ-IFKAHUTRSA-N
CAS Number
CAS 279238-68-5
PubChem Compound ID
5497186
PubChem Substance ID
841861, 7980079, 14782127, 14806612, 39477479, 50175355, 92308768, 96024345, 103697951, 129588491, 134224518, 135060468, 135650689, 135676594, 137237413, 139813978, 160849169, 170494984, 178100673, 198943750, 223446576, 224002767, 237136685
Target and Pathway
Target(s) Delta-type opioid receptor Target Info Antagonist [535501]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539015(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1641).
Ref 535501Delta-opioid receptor antagonists as a new concept for central acting antitussive drugs. Pulm Pharmacol Ther. 2002;15(3):235-40.

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