Target General Infomation
Target ID
T59082
Former ID
TTDR00854
Target Name
Membrane-associated lectin type-C
Gene Name
CD209
Synonyms
CD 209; DC-SIGN; DC-SIGN1; DC-specific ICAM-3 grabbing nonintegrin; Dendritic cell-specific ICAM-3-grabbing nonintegrin 1; MDC-SIGN1A type I isoform; Probable mannose-binding C-type lectin DC-SIGN; Surface C-type lectin DC-SIGN; CD209
Target Type
Research
Function
On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.
BioChemical Class
Transmembrane protein
UniProt ID
Sequence
MSDSKEPRLQQLGLLEEEQLRGLGFRQTRGYKSLAGCLGHGPLVLQLLSFTLLAGLLVQV
SKVPSSISQEQSRQDAIYQNLTQLKAAVGELSEKSKLQEIYQELTQLKAAVGELPEKSKL
QEIYQELTRLKAAVGELPEKSKLQEIYQELTWLKAAVGELPEKSKMQEIYQELTRLKAAV
GELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQ
ELTQLKAAVERLCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQ
NFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFS
GNGWNDDKCNLAKFWICKKSAASCSRDEEQFLSPAPATPNPPPA
Structure
1K9I; 1SL4; 1SL5; 2B6B; 2IT5; 2IT6; 2XR5; 2XR6
Inhibitor Alpha-D-Mannose Drug Info [551393]
Fucose Drug Info [551393]
Pathways
KEGG Pathway Phagosome
Tuberculosis
Measles
Reactome CD209 (DC-SIGN) signaling
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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