Target Information

Target General Infomation
Target ID
T21507
Former ID
TTDR00309
Target Name
Fatty acid-bindingprotein, epidermal
Gene Name
FABP5
Synonyms
E-FABP; Fatty Acid BindingProtein mal1; PA-FABP; Psoriasis-associated fatty acid-binding protein homolog; FABP5
Target Type
Research
Function
High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.
BioChemical Class
Fatty acid bindingprotein
Target Validation
T21507
UniProt ID
Q01469
Sequence
MATVQQLEGRWRLVDSKGFDEYMKELGVGIALRKMGAMAKPDCIITCDGKNLTIKTESTL
KTTQFSCTLGEKFEETTADGRKTQTVCNFTDGALVQHQEWDGKESTITRKLKDGKLVVEC
VMNNVTCTRIYEKVE
Inhibitor 2-(2,3-bis(2-chlorobenzyloxy)phenyl)acetic acid Drug Info [528353]
2-(Carbazole-9-sulfonyl)-benzoic acid Drug Info [527208]
4-Carbazol-9-yl-butyric acid Drug Info [527208]
5-Carbazol-9-yl-pentanoic acid Drug Info [527208]
BMS-480404 Drug Info [528353]
Hexadecanoic acid Drug Info [527208]
Pathways
KEGG Pathway PPAR signaling pathway
NetPath Pathway IL1 Signaling Pathway
Reactome Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
References
Ref 527208Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8.Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target.
Ref 528353J Med Chem. 2006 Aug 10;49(16):5013-7.NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.