Target Information
Target General Infomation | |||||
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Target ID |
T94621
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Former ID |
TTDI00101
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Target Name |
BCAM-AKT2 fusion gene
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Gene Name |
AKT2
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Synonyms |
PKB beta; Protein kinase B beta; RAC-PK-beta; RAC-beta serine/threonine-protein kinase; AKT2
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Target Type |
Research
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Function |
Laminin alpha-5 receptor. May mediate intracellular signaling.
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BioChemical Class |
Kinase
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UniProt ID | |||||
EC Number |
EC 2.7.11.1
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Sequence |
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR E |
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Structure |
1GZK; 1GZN; 1GZO; 1MRV; 1MRY; 1O6K; 1O6L; 1P6S; 2JDO; 2JDR; 2UW9; 2X39; 2XH5; 3D0E; 3E87; 3E88; 3E8D; 2PET; 2PF6
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Pathways | |||||
Reactome | Activation of BAD and translocation to mitochondria | ||||
GPVI-mediated activation cascade | |||||
PIP3 activates AKT signaling | |||||
Translocation of GLUT4 to the plasma membrane | |||||
Activation of AKT2 | |||||
AKT phosphorylates targets in the cytosol | |||||
AKT phosphorylates targets in the nucleus | |||||
Negative regulation of the PI3K/AKT network | |||||
AKT-mediated inactivation of FOXO1A | |||||
Deactivation of the beta-catenin transactivating complex | |||||
CD28 dependent PI3K/Akt signaling | |||||
CTLA4 inhibitory signaling | |||||
gamma signalling through PI3Kgamma | |||||
VEGFR2 mediated vascular permeability | |||||
TP53 Regulates Metabolic Genes | |||||
Constitutive Signaling by AKT1 E17K in Cancer | |||||
References | |||||
Ref 527396 | Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors. Bioorg Med Chem Lett. 2005 Feb 1;15(3):761-4. |
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