| Drug General Information |
| Drug ID |
D0M9QJ
|
| Former ID |
DIB020715
|
| Drug Name |
PHT-427
|
| Synonyms |
PHT 427; PHT427
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C20H31N3O2S2
|
| InChI |
InChI=1S/C20H31N3O2S2/c1-2-3-4-5-6-7-8-9-10-11-12-18-13-15-19(16-14-18)27(24,25)23-20-22-21-17-26-20/h13-17H,2-12H2,1H3,(H,22,23)
|
| InChIKey |
BYWWNRBKPCPJMG-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
85260779, 97080358, 99381500, 103719331, 104158730, 104253210, 124757336, 125164140, 136340169, 136348251, 136367546, 136946510, 138536515, 152258383, 160647220, 162011692, 162037665, 163685772, 174006508, 174526500, 180386847, 185973855, 223382614, 223705082, 224506936, 225331053, 226627378, 241377076, 242586968, 248989086, 249565689, 252158201, 252160525, 252220182, 252473073
|
| Target and Pathway |
| Target(s) |
3-phosphoinositide dependent protein kinase-1 |
Target Info |
Inhibitor |
[2]
|
|---|
| BCAM-AKT2 fusion gene |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
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PPAR signaling pathway
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FoxO signaling pathway
|
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Sphingolipid signaling pathway
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mTOR signaling pathway
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PI3K-Akt signaling pathway
|
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AMPK signaling pathway
|
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Focal adhesion
|
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T cell receptor signaling pathway
|
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Fc epsilon RI signaling pathway
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Neurotrophin signaling pathway
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Insulin signaling pathway
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Thyroid hormone signaling pathway
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Aldosterone-regulated sodium reabsorption
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Toxoplasmosis
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Hepatitis C
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Proteoglycans in cancer
|
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Endometrial cancer
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Prostate cancer
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Non-small cell lung cancer
|
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Choline metabolism in cancer
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PANTHER Pathway
|
Inflammation mediated by chemokine and cytokine signaling pathway
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Insulin/IGF pathway-protein kinase B signaling cascade
|
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Interleukin signaling pathway
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PDGF signaling pathway
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PI3 kinase pathway
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p53 pathway
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Ras Pathway
|
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p53 pathway feedback loops 2
|
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CCKR signaling map ST
|
|
Pathway Interaction Database
|
BCR signaling pathway
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Insulin Pathway
|
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TCR signaling in naï
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
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TCR signaling in naï
|
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FAS (CD95) signaling pathway
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mTOR signaling pathway
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CXCR4-mediated signaling events
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IGF1 pathway
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Class I PI3K signaling events
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ErbB1 downstream signaling
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IL8- and CXCR2-mediated signaling events
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CXCR3-mediated signaling events
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VEGFR1 specific signals
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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Signaling events mediated by VEGFR1 and VEGFR2
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Class I PI3K signaling events mediated by Akt
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IL8- and CXCR1-mediated signaling events
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Trk receptor signaling mediated by PI3K and PLC-gamma
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FGF signaling pathway
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TGF-beta receptor signaling
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PathWhiz Pathway
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Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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Insulin Signalling
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Reactome
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GPVI-mediated activation cascade
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PIP3 activates AKT signaling
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Activation of AKT2
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Role of LAT2/NTAL/LAB on calcium mobilization
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FCERI mediated NF-kB activation
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Integrin alphaIIb beta3 signaling
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CD28 dependent PI3K/Akt signaling
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CTLA4 inhibitory signaling
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G beta:gamma signalling through PI3Kgamma
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VEGFR2 mediated vascular permeability
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VEGFR2 mediated cell proliferation
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CLEC7A (Dectin-1) signaling
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RHO GTPases activate PKNs
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Constitutive Signaling by AKT1 E17K in CancerR-HSA-111447:Activation of BAD and translocation to mitochondria
|
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Translocation of GLUT4 to the plasma membrane
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AKT phosphorylates targets in the cytosol
|
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AKT phosphorylates targets in the nucleus
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Negative regulation of the PI3K/AKT network
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AKT-mediated inactivation of FOXO1A
|
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Deactivation of the beta-catenin transactivating complex
|
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TP53 Regulates Metabolic Genes
|
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Constitutive Signaling by AKT1 E17K in Cancer
|
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WikiPathways
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Serotonin HTR1 Group and FOS Pathway
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TCR Signaling Pathway
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Insulin Signaling
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EGF/EGFR Signaling Pathway
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Focal Adhesion
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Cardiac Hypertrophic Response
|
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Fc epsilon receptor (FCERI) signaling
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Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
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Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
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PIP3 activates AKT signaling
|
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BDNF signaling pathway
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Interleukin-11 Signaling Pathway
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B Cell Receptor Signaling Pathway
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Signaling Pathways in Glioblastoma
|
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TSH signaling pathway
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TCR signaling
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Signaling by Insulin receptor
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Integrin-mediated Cell Adhesion
|
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GPVI-mediated activation cascade
|
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GPCR downstream signaling
|
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Costimulation by the CD28 family
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MicroRNAs in cardiomyocyte hypertrophy
|
| References |
| REF 1 | Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorg Med Chem. 2009 Oct 1;17(19):6983-92. |
|---|
| REF 2 | Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Mol Cancer Ther. 2010 Mar;9(3):706-17. |
|---|
