Target Information
Target General Infomation | |||||
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Target ID |
T47081
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Former ID |
TTDS00323
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Target Name |
Peptidyl-prolyl cis-trans isomerase A
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Gene Name |
PPIA
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Synonyms |
CyPA; Cyclophilin A; Cyclosporin A-binding protein; PPIase; Rotamase; PPIA
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Target Type |
Successful
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Disease | Dietary shortage [ICD9: 260-269; ICD10: E40-E46] | ||||
Function |
Ppiases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
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BioChemical Class |
Cis-trans-isomerases
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UniProt ID | |||||
EC Number |
EC 5.2.1.8
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Sequence |
MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGF
MCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTE WLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE |
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Drugs and Mode of Action | |||||
Inhibitor | (3r)-1-Acetyl-3-Methylpiperidine | Drug Info | [551393] | ||
1-(3-benzyloxy-pyridin-2-yl)-3-phenyl-urea | Drug Info | [527996] | |||
3-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzamide | Drug Info | [527996] | |||
4-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzamide | Drug Info | [527996] | |||
7-AMINO-4-METHYL-CHROMEN-2-ONE | Drug Info | [551374] | |||
Ethyl Oxo(Piperidin-1-Yl)Acetate | Drug Info | [551374] | |||
Binder | L-Proline | Drug Info | [537008] | ||
Pathways | |||||
Reactome | Platelet degranulation | ||||
Uncoating of the HIV Virion | |||||
Budding and maturation of HIV virion | |||||
Integration of provirus | |||||
Early Phase of HIV Life Cycle | |||||
Minus-strand DNA synthesis | |||||
Plus-strand DNA synthesis | |||||
Binding and entry of HIV virion | |||||
Assembly Of The HIV Virion | |||||
APOBEC3G mediated resistance to HIV-1 infection | |||||
Basigin interactions | |||||
WikiPathways | Signaling by the B Cell Receptor (BCR) | ||||
Host Interactions of HIV factors | |||||
HIV Life Cycle | |||||
JAK/STAT | |||||
Cell surface interactions at the vascular wall | |||||
References |
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