Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((1-(2-(4-(3-hydroxypropyl)piperazin-1-yl)ethyl)-5-methoxy-2-methyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| mTOR --- PI3K gamma | (3-(9-(1-(2,4-difluorophenyl)piperidin-4-yl)-6-morpholino-9H-purin-2-yl)phenyl)methanol | Drug Info |
| mTOR --- PI3K gamma | (3-(3-(1-benzylpiperidin-4-yl)-7-morpholino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)phenyl)methanol | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(pyridazin-4-yl)urea | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)-3-methylurea | Drug Info |
| mTOR --- PI3K gamma | 3-(9-(1-((6-methoxypyridin-3-yl)methyl)piperidin-4-yl)-6-morpholino-9H-purin-2-yl)phenol | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)-3-(piperidin-1-yl)urea | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(hydroxymethyl)phenyl)urea | Drug Info |
| mTOR --- PI3K gamma | 3-(6-morpholino-9H-purin-2-yl)phenol | Drug Info |
| mTOR --- PI3K gamma | 2-(6-morpholino-9H-purin-2-yl)phenol | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(1,4'-bipiperidine-1'-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)urea | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-cyanophenyl)urea | Drug Info |
| mTOR --- PI3K gamma | N-(2-(Dimethylamino)ethyl)-4-(3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)ureido)-N-methylbenzamide Hydrochloride | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3]triazolo-[4,5-d]pyrimidin-5-yl)phenyl]-3-pyridin-3-ylurea | Drug Info |
| mTOR --- PI3K gamma | (3-(6-morpholino-9-(1-(4-(pyridin-4-yl)benzyl)piperidin-4-yl)-9H-purin-2-yl)phenyl)methanol | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(2-chloropyridin-4-yl)urea | Drug Info |
| mTOR --- PI3K gamma | (3-(6-morpholino-9-(1-(pyridin-2-ylmethyl)piperidin-4-yl)-9H-purin-2-yl)phenyl)methanol | Drug Info |
| mTOR --- PI3K gamma | methyl 4-[6-(4-{[(2-fluoroethyl)carbamoyl]amino}phenyl)-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate | Drug Info |
| mTOR --- PI3K gamma | 4-({[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-5-yl)phenyl]carbamoyl}amino)-N,N-dimethylbenzamide | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-2-methyl-1-(2-morpholinoethyl)-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-phenyl]-3-{4-[(4-methylpiperazine-1-yl)carbonyl]phenyl}urea Hydrochloride | Drug Info |
| mTOR --- PI3K gamma | 3-(6-morpholino-9-(1-((6-morpholinopyridin-3-yl)methyl)piperidin-4-yl)-9H-purin-2-yl)phenol | Drug Info |
| mTOR --- PI3K gamma | 2-((5-bromo-2-methyl-1H-indol-3-yl)methylene)-4,6-dihydroxybenzofuran-3(2H)-one | Drug Info |
| mTOR --- PI3K gamma | 5-(9-(1-(4-chlorobenzyl)piperidin-4-yl)-6-morpholino-9H-purin-2-yl)pyridin-3-ol | Drug Info |
| mTOR --- PI3K gamma | N-(2-(dimethylamino)ethyl)-4-(3-(4-(4-methoxy-6-morpholino-1,3,5-triazin-2-yl)phenyl)ureido)-N-methylbenzamide | Drug Info |
| mTOR --- PI3K gamma | 4-({[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-5-yl)phenyl]carbamoyl}amino)-N-[2-(4-methylpiperazin-1-yl)ethyl]benzamide | Drug Info |
| mTOR --- PI3K gamma | 1-(2,3'-bipyridin-5-yl)-3-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phenyl]-3-[4-(hydroxymethyl)phenyl]urea | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phenyl]-3-pyridin-3-ylurea | Drug Info |
| mTOR --- PI3K gamma | 2-((1-(2-(dimethylamino)ethyl)-5-methoxy-2-methyl-1H-indol-3-yl)methylene)-4,6-dihydroxybenzofuran-3(2H)-one | Drug Info |
| mTOR --- PI3K gamma | 3-(9-(1-((5-chloropyridin-3-yl)methyl)piperidin-4-yl)-6-morpholino-9H-purin-2-yl)phenol | Drug Info |
| mTOR --- PI3K gamma | isopropyl 4-(6-{4-[(cyclopropylcarbamoyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate | Drug Info |
| mTOR --- PI3K gamma | (3-(9-(1-(2-fluorobenzyl)piperidin-4-yl)-6-morpholino-9H-purin-2-yl)phenyl)methanol | Drug Info |
| mTOR --- PI3K gamma | 3-(9-(1-benzylpiperidin-4-yl)-6-morpholino-9H-purin-2-yl)phenol | Drug Info |
| mTOR --- PI3K gamma | 4-(2-(thiophen-2-yl)-9H-purin-6-yl)morpholine | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-((4-methylpiperazin-1-yl)methyl)phenyl)urea | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-1-(3-morpholinopropyl)-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| mTOR --- PI3K gamma | 4-(2-(benzo[d][1,3]dioxol-5-yl)-9H-purin-6-yl)morpholine | Drug Info |
| mTOR --- PI3K gamma | 4-{3-[4-(3-Isopropyl-7-morpholin-4-yl-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-5-yl)phenyl]ureido}benzamide | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((1-(2-(4-(3-hydroxypropyl)piperazin-1-yl)ethyl)-5-methoxy-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-methylpiperazine-1-carbonyl)phenyl)-3-(4-(6-morpholino-4-oxo-1,4-dihydro-1,3,5-triazin-2-yl)phenyl)urea | Drug Info |
| mTOR --- PI3K gamma | 4-({[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-5-yl)phenyl]carbamoyl}amino)-N-(2-pyridin-2-ylethyl)benzamide | Drug Info |
| mTOR --- PI3K gamma | N-[2-(Dimethylamino)ethyl]-4-({[4-(3-ethyl-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)phenyl]-carbamoyl}amino)benzamide | Drug Info |
| mTOR --- PI3K gamma | 4-(2-(1H-indol-6-yl)-9H-purin-6-yl)morpholine | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-methylpiperazin-1-yl)phenyl)urea | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(pyrimidin-5-yl)urea | Drug Info |
| mTOR --- PI3K gamma | tert-Butyl 4-(6-(4-(3-Methylureido)phenyl)-4-morpholino-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(3-Cyclopropyl-7-morpholino-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-5-yl)phenyl)-3-(pyridin-3-yl)urea | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(2-(3-(hydroxymethyl)phenyl)-6-morpholino-9H-purin-9-yl)piperidin-1-yl)ethanone | Drug Info |
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