Drug Information

Drug General Information
Drug ID
DXX7RZ
Drug Name
4-(((3-chlorophenyl)(6-(dimethylamino)pyrimidin-4-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one
Synonyms
CHEMBL1944890
Indication Discovery agent Investigative [1587926]
Formula
C22H18ClF2N5O
Canonical SMILES
CN(C)c1cc(ncn1)N(CC2=CC(=O)Nc3c(F)c(F)ccc23)c4cccc(Cl)c4
InChI
InChI=1S/C22H18ClF2N5O/c1-29(2)18-10-19(27-12-26-18)30(15-5-3-4-14(23)9-15)11-13-8-20(31)28-22-16(13)6-7-17(24)21(22)25/h3-10,12H,11H2,1-2H3,(H,28,31)
InChIKey
QSENFNYYTINYEE-UHFFFAOYSA-N
Target and Pathway
Target(s) Nitric-oxide synthase, brain Target Info [1587926]
Nitric oxide synthase, inducible Target Info [1587926]
BioCyc Pathway Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cycle
KEGG Pathway Arginine and proline metabolism
Metabolic pathways
Calcium signaling pathway
Phagosome
Circadian entrainment
Long-term depression
Salivary secretion
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)hsa00220:Arginine biosynthesis
HIF-1 signaling pathway
Peroxisome
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Tuberculosis
Pathways in cancer
Small cell lung cancer
NetPath Pathway EGFR1 Signaling PathwayNetPath_13:IL1 Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway CCKR signaling map ST
Pathway Interaction Database IL12-mediated signaling events
Alpha9 beta1 integrin signaling events
ATF-2 transcription factor network
IL23-mediated signaling events
Signaling mediated by p38-alpha and p38-beta
HIF-1-alpha transcription factor network
PathWhiz Pathway Arginine and Proline Metabolism
Reactome ROS production in response to bacteria
Nitric oxide stimulates guanylate cyclaseR-HSA-1222556:ROS production in response to bacteria
Nitric oxide stimulates guanylate cyclase
WikiPathways Monoamine Transport
Myometrial Relaxation and Contraction Pathways
Amyotrophic lateral sclerosis (ALS)
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
Spinal Cord Injury
Alzheimers Disease
Effects of Nitric Oxide
Serotonin Transporter ActivityWP619:Type II interferon signaling (IFNG)
AGE/RAGE pathway
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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