Drug General Information
Drug ID
D0Y6SN
Former ID
DCL000976
Drug Name
SB-277011
Synonyms
SB 277011; SB 277011A; SB 277011-A; N-[4-[2-(6-cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl]quinoline-4-carboxamide
Drug Type
Small molecular drug
Indication Schizophrenia [ICD9: 295; ICD10:F20] Terminated [536463], [538907]
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL

Formula
C28H30N4O
InChI
InChI=1S/C28H30N4O/c29-18-21-5-8-23-19-32(16-13-22(23)17-21)15-12-20-6-9-24(10-7-20)31-28(33)26-11-14-30-27-4-2-1-3-25(26)27/h1-5,8,11,14,17,20,24H,6-7,9-10,12-13,15-16,19H2,(H,31,33)/t20-,24-
InChIKey
OLWRVVHPJFLNPW-LSNLESRRSA-N
CAS Number
CAS 304853-42-7
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) D(3) dopamine receptor Target Info Antagonist [536463]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapse
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, Other
References
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.
Ref 538907(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 143).
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.

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