Drug Information

Drug General Information
Drug ID
D0X6XH
Former ID
DNCL003120
Drug Name
CM-2395
Indication Schizophrenia [ICD9: 295; ICD10:F20] Phase 3 [551513]
Company
Cenomed BioSciences
Target and Pathway
Target(s) D(3) dopamine receptor Target Info Agonist [548980]
Sigma(1)-type opioid receptor Target Info Agonist [548980]
5-hydroxytryptamine 1A receptor Target Info Agonist [548980]
D(4) dopamine receptor Target Info Agonist [548980]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapsehsa04080:Neuroactive ligand-receptor interaction
Dopaminergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP2006:miR-targeted genes in squamous cell - TarBase
miR-targeted genes in lymphocytes - TarBaseWP722:Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
GPCRs, Other
References
Ref 551513Pharmaceutical Research Companies Are Developing More Than 300 Medicines to Treat Mental Illnesses. Pharmaceutical Research and Manufacturers of America report.2010.
Ref 548980Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031127)

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