| Drug General Information |
| Drug ID |
D0W6JO
|
| Former ID |
DNC007532
|
| Drug Name |
QUISQUALATE
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C5H7N3O5
|
| InChI |
InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
|
| InChIKey |
ASNFTDCKZKHJSW-REOHCLBHSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
10494, 829151, 3153217, 7890168, 7980474, 8176644, 11113399, 14867669, 17405597, 17436194, 24278004, 24770702, 26751639, 34706304, 46392526, 46392527, 46392847, 46509075, 46517821, 47170012, 47193871, 47589201, 47736719, 48110694, 50064863, 50104331, 50104332, 53786831, 57312446, 79846616, 85164420, 90341112, 91702071, 92303337, 103195075, 104050226, 104334657, 117593873, 118696079, 121362063, 124750188, 124800475, 127453052, 134344737, 135004298, 135650876, 135651194, 135676646, 135685944, 135697895
|
| Target and Pathway |
| Target(s) |
Glutamate receptor, ionotropic kainate 1 |
Target Info |
Inhibitor |
[2]
|
|---|
| Metabotropicglutamate receptor 1 |
Target Info |
Inhibitor |
[3]
|
| Metabotropic glutamate receptor |
Target Info |
Inhibitor |
[3]
|
| Metabotropic glutamate receptor 7 |
Target Info |
Inhibitor |
[3]
|
| Metabotropic glutamate receptor 2 |
Target Info |
Inhibitor |
[3]
|
| Metabotropic glutamate receptor3 |
Target Info |
Inhibitor |
[3]
|
| Metabotropic glutamate receptor 8 |
Target Info |
Inhibitor |
[3]
|
| Metabotropic glutamate receptor 5 |
Target Info |
Inhibitor |
[3]
|
| Glutamate carboxypeptidase II |
Target Info |
Inhibitor |
[4]
|
|
KEGG Pathway
|
Neuroactive ligand-receptor interaction
|
|
Glutamatergic synapsehsa04020:Calcium signaling pathway
|
|
FoxO signaling pathway
|
|
Gap junction
|
|
Long-term potentiation
|
|
Retrograde endocannabinoid signaling
|
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Glutamatergic synapse
|
|
Long-term depression
|
|
Estrogen signaling pathwayhsa04080:Neuroactive ligand-receptor interaction
|
|
Glutamatergic synapsehsa04080:Neuroactive ligand-receptor interaction
|
|
Cocaine addictionhsa04080:Neuroactive ligand-receptor interaction
|
|
Huntington's diseasehsa00250:Alanine, aspartate and glutamate metabolism
|
|
Metabolic pathways
|
|
Vitamin digestion and absorption
|
|
NetPath Pathway
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TCR Signaling Pathway
|
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TNFalpha Signaling Pathway
|
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PANTHER Pathway
|
Huntington disease
|
|
Ionotropic glutamate receptor pathway
|
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Metabotropic glutamate receptor group III pathway
|
|
Metabotropic glutamate receptor group I pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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Metabotropic glutamate receptor group I pathway
|
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Endogenous cannabinoid signalingP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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Metabotropic glutamate receptor group III pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Metabotropic glutamate receptor group II pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Metabotropic glutamate receptor group III pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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Endogenous cannabinoid signaling
|
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Reactome
|
G alpha (q) signalling events
|
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Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-418594:G alpha (i) signalling events
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Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-416476:G alpha (q) signalling events
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Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-70614:Amino acid synthesis and interconversion (transamination)
|
|
WikiPathways
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellWP666:Hypothetical Network for Drug Addiction
|
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GPCRs, Class C Metabotropic glutamate, pheromone
|
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Gastrin-CREB signalling pathway via PKC and MAPK
|
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GPCR ligand binding
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GPCR downstream signaling
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GPCRs, OtherWP501:GPCRs, Class C Metabotropic glutamate, pheromone
|
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GPCR downstream signalingWP501:GPCRs, Class C Metabotropic glutamate, pheromone
|
|
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
|
|
GPCR downstream signalingWP241:One Carbon Metabolism
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1372). |
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| REF 2 | J Med Chem. 2008 Jul 24;51(14):4093-103. Epub 2008 Jun 25.Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation ofionotropic glutamate receptor subtypes 5, 6, and 7. |
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| REF 3 | J Med Chem. 1998 Mar 12;41(6):930-9.Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid. |
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| REF 4 | J Med Chem. 2007 Jul 12;50(14):3267-73. Epub 2007 Jun 14.Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II. |
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