Drug Information

Drug General Information
Drug ID
D0V5SC
Former ID
DIB016644
Drug Name
Liproca Depot
Synonyms
Liproca; 2-hydroxyflutamide; 2-hydroxyflutamide implant (injectable, controlled release), Lidds
Indication Prostate cancer [ICD9: 185; ICD10:C61] Phase 2 [525060]
Company
LIDDS AB
Structure
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2D MOL

3D MOL
Canonical SMILES
c1(c(ccc(c1)NC(=O)C(C)(C)O)[N+](=O)[O-])C(F)(F)F
Target and Pathway
Target(s) Androgen receptor Target Info Antagonist [527745]
KEGG Pathway Oocyte meiosis
Pathways in cancer
Prostate cancer
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY network
Reactome Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathway
References
Ref 525060ClinicalTrials.gov (NCT02341404) A Study of 2-hydroxyflutamide (Liproca Depot), Injected Into the Prostate in Patients With Localized Prostate Cancer. U.S. National Institutes of Health.
Ref 527745Effects of dihydrotestosterone and hydroxyflutamide on androgen receptors in cultured human breast cancer cells (EVSA-T). J Steroid Biochem Mol Biol. 1992 Jun;42(5):547-54.

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