| Drug General Information |
| Drug ID |
D0U5YT
|
| Former ID |
DIB018101
|
| Drug Name |
(S)-3HPG
|
| Synonyms |
3-hydroxyphenylglycine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C8H9NO3
|
| InChI |
InChI=1S/C8H9NO3/c9-7(8(11)12)5-2-1-3-6(10)4-5/h1-4,7,10H,9H2,(H,11,12)/t7-/m0/s1
|
| InChIKey |
DQLYTFPAEVJTFM-ZETCQYMHSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
11113447, 11113448, 11646491, 26751677, 43224454, 75240233, 96052583, 103217176, 103950268, 114637871, 132557902, 135650424, 163127049, 170507316, 223550757, 238041119, 241130071, 241181618, 249615235
|
| Target and Pathway |
| Target(s) |
Metabotropic glutamate receptor 5 |
Target Info |
Agonist |
[2]
|
|---|
| Metabotropicglutamate receptor 1 |
Target Info |
Agonist |
[2]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Gap junction
|
|
Long-term potentiation
|
|
Retrograde endocannabinoid signaling
|
|
Glutamatergic synapse
|
|
Huntington's diseasehsa04020:Calcium signaling pathway
|
|
FoxO signaling pathway
|
|
Long-term depression
|
|
Estrogen signaling pathway
|
|
PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Metabotropic glutamate receptor group III pathway
|
|
Metabotropic glutamate receptor group I pathway
|
|
Endogenous cannabinoid signalingP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Endogenous cannabinoid signaling
|
|
Reactome
|
G alpha (q) signalling events
|
|
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-416476:G alpha (q) signalling events
|
|
Class C/3 (Metabotropic glutamate/pheromone receptors)
|
|
WikiPathways
|
Hypothetical Network for Drug Addiction
|
|
GPCRs, Class C Metabotropic glutamate, pheromone
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
GPCR ligand binding
|
|
GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
|
|
GPCR downstream signaling
|
|
GPCRs, Other
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1366). |
|---|
| REF 2 | Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601. |
|---|
