Drug General Information
Drug ID	D0U5UC
Former ID	DIB006339
Drug Name	KD025
Indication	Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06]		Phase 2	[525025]
Company	Kadmon
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Rho associated protein kinase 2	Target Info	Inhibitor	[533023]
KEGG Pathway	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Chemokine signaling pathway
	Sphingolipid signaling pathway
	Vascular smooth muscle contraction
	Wnt signaling pathway
	Axon guidance
	Focal adhesion
	Platelet activation
	Leukocyte transendothelial migration
	Regulation of actin cytoskeleton
	Oxytocin signaling pathway
	Pathogenic Escherichia coli infection
	Shigellosis
	Salmonella infection
	Pathways in cancer
	Proteoglycans in cancer
PANTHER Pathway	Cytoskeletal regulation by Rho GTPase
Pathway Interaction Database	RhoA signaling pathway
	Plasma membrane estrogen receptor signaling
	Osteopontin-mediated events
	PLK1 signaling events
	PAR4-mediated thrombin signaling events
	PAR1-mediated thrombin signaling events
	Signaling events mediated by focal adhesion kinase
Reactome	EPHB-mediated forward signaling
	EPHA-mediated growth cone collapse
	G alpha (12/13) signalling events
	Sema4D induced cell migration and growth-cone collapse
	VEGFA-VEGFR2 Pathway
	RHO GTPases Activate ROCKs
WikiPathways	G13 Signaling Pathway
	Regulation of Actin Cytoskeleton
	Focal Adhesion
	JAK/STAT
	Spinal Cord Injury
	Pathogenic Escherichia coli infection
	Leptin signaling pathway
	Semaphorin interactions
	Integrin-mediated Cell Adhesion
	GPCR downstream signaling
	MicroRNAs in cardiomyocyte hypertrophy
	Androgen receptor signaling pathway
References
Ref 525025	ClinicalTrials.gov (NCT02317627) Study of of KD025 in Subjects With Psoriasis Vulgaris Who Failed First-Line Therapy. U.S. National Institutes of Health.
Ref 533023	Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16814-9.

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