Drug Information

Drug General Information
Drug ID
D0U3DX
Former ID
DIB009657
Drug Name
Mannose phosphate
Drug Type
Small molecular drug
Indication Lesion [ICD10:S00-T98] Discontinued in Phase 2 [532992]
Company
Santa Cruz Biotechnology
Structure
Download
2D MOL

3D MOL
Formula
C6H15O10P
Canonical SMILES
C(C(C(C(C(C=O)O)O)O)O)O.OP(=O)(O)O
InChI
1S/C6H12O6.H3O4P/c7-1-3(9)5(11)6(12)4(10)2-8;1-5(2,3)4/h1,3-6,8-12H,2H2;(H3,1,2,3,4)/t3-,4-,5-,6-;/m1./s1
InChIKey
NDVRKEKNSBMTAX-MVNLRXSJSA-N
PubChem Compound ID
73014169
PubChem Substance ID
163781963, 226629313
Target and Pathway
Target(s) Transforming growth factor beta 1 Target Info Modulator [533229]
KEGG Pathway MAPK signaling pathway
Cytokine-cytokine receptor interaction
FoxO signaling pathway
Cell cycle
Endocytosis
TGF-beta signaling pathway
Osteoclast differentiation
Hippo signaling pathway
Intestinal immune network for IgA production
Non-alcoholic fatty liver disease (NAFLD)
Leishmaniasis
Chagas disease (American trypanosomiasis)
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Hepatitis B
HTLV-I infection
Pathways in cancer
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Chronic myeloid leukemia
Inflammatory bowel disease (IBD)
Rheumatoid arthritis
Hypertrophic cardiomyopathy (HCM)
Dilated cardiomyopathy
NetPath Pathway TCR Signaling Pathway
IL3 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database Glypican 1 network
IL27-mediated signaling events
Regulation of Telomerase
RXR and RAR heterodimerization with other nuclear receptor
AP-1 transcription factor network
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
ALK1 signaling events
Syndecan-1-mediated signaling events
Syndecan-2-mediated signaling events
TGF-beta receptor signaling
IL12 signaling mediated by STAT4
Reactome Platelet degranulation
Molecules associated with elastic fibres
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Syndecan interactions
ECM proteoglycans
SMAD2/3 Phosphorylation Motif Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
Transcriptional regulation of white adipocyte differentiation
WikiPathways DNA Damage Response (only ATM dependent)
TCR Signaling Pathway
Senescence and Autophagy in Cancer
TGF Beta Signaling Pathway
ACE Inhibitor Pathway
Cytokines and Inflammatory Response
Endochondral Ossification
MAPK Signaling Pathway
TGF beta Signaling Pathway
NRF2 pathway
Nuclear Receptors Meta-Pathway
Vitamin D Receptor Pathway
Aryl Hydrocarbon Receptor Pathway
Extracellular vesicle-mediated signaling in recipient cells
IL-3 Signaling Pathway
Dopaminergic Neurogenesis
Endoderm Differentiation
Hematopoietic Stem Cell Differentiation
Differentiation Pathway
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Cardiac Hypertrophic Response
Syndecan interactions
Host Interactions with Influenza Factors
Transcriptional Regulation of White Adipocyte Differentiation
Signaling by TGF-beta Receptor Complex
Extracellular matrix organization
Elastic fibre formation
Primary Focal Segmental Glomerulosclerosis FSGS
Spinal Cord Injury
Cardiac Progenitor Differentiation
Integrated Pancreatic Cancer Pathway
Adipogenesis
Corticotropin-releasing hormone
Interleukin-11 Signaling Pathway
Allograft Rejection
Cell Cycle
TFs Regulate miRNAs related to cardiac hypertrophy
MicroRNAs in cardiomyocyte hypertrophy
References
Ref 532992Mannose phosphate isomerase regulates fibroblast growth factor receptor family signaling and glioma radiosensitivity. PLoS One. 2014 Oct 14;9(10):e110345.
Ref 533229The mannose-6-phosphate analogue, PXS64, inhibits fibrosis via TGF-beta1 pathway in human lung fibroblasts. Immunol Lett. 2015 Jun;165(2):90-101.

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