| Drug General Information |
| Drug ID |
D0TN0D
|
| Former ID |
DNC008747
|
| Drug Name |
METAZOCINE
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C15H21NO
|
| Canonical SMILES |
CC1C2CC3=C(C1(CCN2C)C)C=C(C=C3)O
|
| InChI |
1S/C15H21NO/c1-10-14-8-11-4-5-12(17)9-13(11)15(10,2)6-7-16(14)3/h4-5,9-10,14,17H,6-8H2,1-3H3
|
| InChIKey |
YGSVZRIZCHZUHB-UHFFFAOYSA-N
|
| CAS Number |
CAS 3734-52-9
|
| PubChem Compound ID |
|
| PubChem Substance ID |
226693, 486200, 5392777, 8188110, 10520681, 11409234, 15121674, 43119625, 47440737, 47960191, 49991676, 49991678, 57314727, 78611269, 103205923, 103937861, 104325991, 117617120, 126422714, 126433873, 129793497, 135020187, 137248647, 143243146, 179294062, 226414221, 241076244, 249778009, 249948677
|
| Target and Pathway |
| Target(s) |
Delta-type opioid receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Kappa-type opioid receptor |
Target Info |
Inhibitor |
[1]
|
| Mu-type opioid receptor |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
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cGMP-PKG signaling pathway
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Sphingolipid signaling pathway
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Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
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Estrogen signaling pathway
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Morphine addiction
|
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Enkephalin release
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Opioid proenkephalin pathway
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Opioid proopiomelanocortin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Opioid prodynorphin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Pathway Interaction Database
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IL4-mediated signaling events
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Reactome
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Peptide ligand-binding receptors
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G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
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G alpha (i) signalling events
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WikiPathways
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GPCRs, Class A Rhodopsin-like
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Peptide GPCRs
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GPCR ligand binding
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GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
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GPCR downstream signalingWP69:TCR Signaling Pathway
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Opioid Signalling
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GPCR downstream signaling
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| References |
| REF 1 | Bioorg Med Chem Lett. 2009 Jan 1;19(1):203-8. Epub 2008 Nov 7.Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. |
|---|
| REF 2 | J Med Chem. 1982 Dec;25(12):1423-7.Synthesis and biological evaluation of a metazocine-containing enkephalinamide. Evidence for nonidentical roles of the tyramine moiety in opiates and opioid peptides. |
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