Drug Information

Drug General Information
Drug ID
D0T4QX
Former ID
DIB012912
Drug Name
CTEP
Synonyms
MGluR5 antagonist (oral), Roche; Metabotropic glutamate receptor 5 antagonist (oral), Roche
Drug Type
Small molecular drug
Indication Fragile X syndrome [ICD9: 332, 759.83; ICD10:F02.3, G20, Q99.2] Investigative [541547]
Company
F Hoffmann-La Roche Ltd
Structure
Download
2D MOL

3D MOL
Formula
C19H13ClF3N3O
InChI
InChI=1S/C19H13ClF3N3O/c1-12-17(8-3-14-9-10-24-18(20)11-14)25-13(2)26(12)15-4-6-16(7-5-15)27-19(21,22)23/h4-7,9-11H,1-2H3
InChIKey
GOHCTCOGYKAJLZ-UHFFFAOYSA-N
PubChem Compound ID
11646823
PubChem Substance ID
16750215, 23749841, 76530209, 162009737, 162221079, 163620884, 163686207, 163781239, 172086186, 178103024, 178103025, 185970157, 226087956, 226910402, 251910641, 252160617, 252440309, 252451820, 252471220
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Antagonist [543750]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 541547(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6409).
Ref 543750(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 293).

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