Drug Information

Drug General Information
Drug ID
D0SE2D
Former ID
DNC010271
Drug Name
6-(4-chlorophenylamino)-N,N-diethylnicotinamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530531]
Structure
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2D MOL

3D MOL
Formula
C16H18ClN3O
Canonical SMILES
CCN(CC)C(=O)C1=CN=C(C=C1)NC2=CC=C(C=C2)Cl
InChI
1S/C16H18ClN3O/c1-3-20(4-2)16(21)12-5-10-15(18-11-12)19-14-8-6-13(17)7-9-14/h5-11H,3-4H2,1-2H3,(H,18,19)
InChIKey
UEKPAIMMZMCKSL-UHFFFAOYSA-N
PubChem Compound ID
23725212
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [530531]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 530531Bioorg Med Chem Lett. 2010 Jan 1;20(1):184-8. Epub 2009 Nov 5.Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity.
Ref 530531Bioorg Med Chem Lett. 2010 Jan 1;20(1):184-8. Epub 2009 Nov 5.Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity.

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