Drug Information

Drug General Information
Drug ID
D0S7WZ
Former ID
DNC003652
Drug Name
(-)-3-(1-Propyl-piperidin-3-yl)-benzonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533938]
Structure
Download
2D MOL

3D MOL
Formula
C15H20N2
Canonical SMILES
CCCN1CCCC(C1)C2=CC=CC(=C2)C#N
InChI
1S/C15H20N2/c1-2-8-17-9-4-7-15(12-17)14-6-3-5-13(10-14)11-16/h3,5-6,10,15H,2,4,7-9,12H2,1H3
InChIKey
GQRIAOUUYRIMLH-UHFFFAOYSA-N
PubChem Compound ID
5119
Target and Pathway
Target(s) D(3) dopamine receptor Target Info Inhibitor [533938]
D(2) dopamine receptor Target Info Inhibitor [533938]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04015:Rap1 signaling pathway
cAMP signaling pathway
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
References
Ref 533938J Med Chem. 1993 Oct 15;36(21):3188-96.Substituted 3-phenylpiperidines: new centrally acting dopamine autoreceptor antagonists.
Ref 533938J Med Chem. 1993 Oct 15;36(21):3188-96.Substituted 3-phenylpiperidines: new centrally acting dopamine autoreceptor antagonists.

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