Drug General Information
Drug ID	D0S7UU
Former ID	DIB000384
Drug Name	PF-06260414
Indication	Cachexia [ICD9: 799.4; ICD10:R64]		Discontinued in Phase 1	[549537]
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Androgen receptor	Target Info	Modulator	[550356]
KEGG Pathway	Oocyte meiosis
	Pathways in cancer
	Prostate cancer
NetPath Pathway	EGFR1 Signaling Pathway
	AndrogenReceptor Signaling Pathway
	FSH Signaling Pathway
Pathway Interaction Database	Regulation of nuclear SMAD2/3 signaling
	Coregulation of Androgen receptor activity
	Regulation of Androgen receptor activity
	Nongenotropic Androgen signaling
	Regulation of nuclear beta catenin signaling and target gene transcription
	FOXA1 transcription factor network
	Notch-mediated HES/HEY network
Reactome	Nuclear Receptor transcription pathway
	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways	SIDS Susceptibility Pathways
	Integrated Pancreatic Cancer Pathway
	Prostate Cancer
	Integrated Breast Cancer Pathway
	Nuclear Receptors
	Androgen receptor signaling pathway
References
Ref 549537	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800040072)
Ref 550356	Phase I clinical trail of PF-06260414 for treating cachexia. Pfizer Inc.

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