Drug Information

Drug General Information
Drug ID
D0RX6I
Former ID
DNC012636
Drug Name
4-((E)-1-Naphthalen-1-yl-propenyl)-1H-imidazole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534160]
Structure
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2D MOL

3D MOL
Formula
C16H14N2
Canonical SMILES
CC=C(C1=CC=CC2=CC=CC=C21)C3=CN=CN3
InChI
1S/C16H14N2/c1-2-13(16-10-17-11-18-16)15-9-5-7-12-6-3-4-8-14(12)15/h2-11H,1H3,(H,17,18)/b13-2+
InChIKey
VDVBKYMIYSQNPM-XNJYKOPJSA-N
PubChem Compound ID
10704862
Target and Pathway
Target(s) Alpha-1A adrenergic receptor Target Info Inhibitor [534160]
Alpha-1D adrenergic receptor Target Info Inhibitor [534160]
Alpha-1B adrenergic receptor Target Info Inhibitor [534160]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04020:Calcium signaling pathway
Salivary secretion
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Pathway Interaction Database LPA receptor mediated events
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
AMPK SignalingWP58:Monoamine GPCRs
GPCRs, OtherWP58:Monoamine GPCRs
Vitamin D Receptor Pathway
AMPK Signaling
References
Ref 534160J Med Chem. 1996 Jul 19;39(15):3001-13.Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene derivatives of medetomidine.
Ref 534160J Med Chem. 1996 Jul 19;39(15):3001-13.Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene derivatives of medetomidine.

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