Drug Information

Drug General Information
Drug ID
D0RR4T
Former ID
DIB016465
Drug Name
GI-270384X
Synonyms
270384
Indication Inflammatory bowel disease [ICD9: 555, 556; ICD10:K50, K51] Terminated [529903]
Company
GlaxoSmithKline Inc
Target and Pathway
Target(s) ICAM-1 Target Info Modulator [529903]
E-selectin Target Info Modulator [529903]
KEGG Pathway NF-kappa B signaling pathway
Cell adhesion molecules (CAMs)
Natural killer cell mediated cytotoxicity
TNF signaling pathway
Leukocyte transendothelial migration
African trypanosomiasis
Malaria
Staphylococcus aureus infection
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Rheumatoid arthritis
Viral myocarditishsa04514:Cell adhesion molecules (CAMs)
NetPath Pathway IL5 Signaling Pathway
IL1 Signaling Pathway
TSH Signaling Pathway
IL6 Signaling Pathway
IL2 Signaling Pathway
ID Signaling Pathway
TWEAK Signaling Pathway
RANKL Signaling Pathway
TNFalpha Signaling PathwayNetPath_17:IL5 Signaling Pathway
IL4 Signaling Pathway
TNFalpha Signaling Pathway
Pathway Interaction Database Thromboxane A2 receptor signaling
Glucocorticoid receptor regulatory network
amb2 Integrin signaling
Beta2 integrin cell surface interactionstxa2pathway:Thromboxane A2 receptor signaling
ATF-2 transcription factor network
Reactome Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions
Interferon gamma signalingR-HSA-202733:Cell surface interactions at the vascular wall
WikiPathways Type II interferon signaling (IFNG)
IL1 and megakaryotyces in obesity
Human Complement System
Spinal Cord Injury
Interleukin-11 Signaling Pathway
RANKL/RANK Signaling Pathway
Integrin cell surface interactions
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient NetworkWP2806:Human Complement System
TNF alpha Signaling Pathway
Cell surface interactions at the vascular wall
References
Ref 529903Inhibition of endothelial cell adhesion molecule expression improves colonic hyperalgaesia. Neurogastroenterol Motil. 2009 Feb;21(2):189-96.
Ref 529903Inhibition of endothelial cell adhesion molecule expression improves colonic hyperalgaesia. Neurogastroenterol Motil. 2009 Feb;21(2):189-96.

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