Drug Information

Drug General Information
Drug ID
D0R8UU
Former ID
DNC005183
Drug Name
1-[2-(2-Benzyl-phenoxy)-ethyl]-piperidine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527160]
Structure
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2D MOL

3D MOL
Formula
C20H25NO
Canonical SMILES
C1CCN(CC1)CCOC2=CC=CC=C2CC3=CC=CC=C3
InChI
1S/C20H25NO/c1-3-9-18(10-4-1)17-19-11-5-6-12-20(19)22-16-15-21-13-7-2-8-14-21/h1,3-6,9-12H,2,7-8,13-17H2
InChIKey
QKRCVHKKBOUVNT-UHFFFAOYSA-N
PubChem Compound ID
44396220
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Inhibitor [527160]
D(4) dopamine receptor Target Info Inhibitor [527160]
Dopamine D1 receptor Target Info Inhibitor [527160]
D(1B) dopamine receptor Target Info Inhibitor [527160]
D(3) dopamine receptor Target Info Inhibitor [527160]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholismhsa04080:Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04020:Calcium signaling pathway
Amphetamine addiction
Morphine addiction
Alcoholismhsa04020:Calcium signaling pathway
Dopaminergic synapsehsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Nicotine pharmacodynamics pathwayP05912:Dopamine receptor mediated signaling pathwayP05912:Dopamine receptor mediated signaling pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
GPCR downstream signalingWP58:Monoamine GPCRs
GPCRs, Other
References
Ref 527160J Med Chem. 2004 Aug 12;47(17):4155-8.Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 receptor selectivity.
Ref 527160J Med Chem. 2004 Aug 12;47(17):4155-8.Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 receptor selectivity.

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