Drug Information

Drug General Information
Drug ID
D0R8TZ
Former ID
DIB020394
Drug Name
MPEP
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538904]
Structure
Download
2D MOL
Formula
C14H11N
InChI
InChI=1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3
InChIKey
NEWKHUASLBMWRE-UHFFFAOYSA-N
PubChem Compound ID
3025961
PubChem Substance ID
6732441, 7980033, 10043728, 11111471, 11113962, 15219891, 24278557, 26752106, 36070851, 47213189, 48393935, 50032786, 50104761, 53011319, 53789543, 56310595, 57352547, 85209181, 85787598, 90340900, 91721550, 103256385, 103983721, 111614268, 124749956, 124880742, 124880743, 124880744, 125541046, 128649834, 128692244, 132558477, 134343330, 135215341, 135610598, 135650628, 137005433, 140862507, 143117037, 152159554, 152258585, 160647421, 162025940, 163782382, 172087036, 177513141, 179235816, 198960489, 203093166, 223402611
Target and Pathway
Target(s) Metabotropic glutamate receptor 4 Target Info Modulator (allosteric modulator) [526594]
Metabotropic glutamate receptor 5 Target Info Modulator (allosteric modulator) [525618]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Taste transductionhsa04020:Calcium signaling pathway
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-416476:G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
References
Ref 538904(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1426).
Ref 5256182-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Neuropharmacology. 1999 Oct;38(10):1493-503.
Ref 526594Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP. Br J Pharmacol. 2003 Mar;138(6):1026-30.

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