Drug General Information |
Drug ID |
D0R6ZS
|
Former ID |
DNC014279
|
Drug Name |
N-(3-bromophenyl)-6-chloroquinazolin-4-amine
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
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2D MOL
3D MOL
|
Formula |
C14H9BrClN3
|
Canonical SMILES |
C1=CC(=CC(=C1)Br)NC2=NC=NC3=C2C=C(C=C3)Cl
|
InChI |
1S/C14H9BrClN3/c15-9-2-1-3-11(6-9)19-14-12-7-10(16)4-5-13(12)17-8-18-14/h1-8H,(H,17,18,19)
|
InChIKey |
NBEFPXHBLZGXNK-UHFFFAOYSA-N
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PubChem Compound ID |
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Target and Pathway |
Target(s) |
Metabotropic glutamate receptor 5 |
Target Info |
Inhibitor |
[1]
|
Metabotropicglutamate receptor 1 |
Target Info |
Inhibitor |
[1]
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KEGG Pathway
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Calcium signaling pathway
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Neuroactive ligand-receptor interaction
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Gap junction
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Long-term potentiation
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Retrograde endocannabinoid signaling
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Glutamatergic synapse
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Huntington's diseasehsa04020:Calcium signaling pathway
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FoxO signaling pathway
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Long-term depression
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Estrogen signaling pathway
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Metabotropic glutamate receptor group III pathway
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Metabotropic glutamate receptor group I pathway
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Endogenous cannabinoid signalingP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Endogenous cannabinoid signaling
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Reactome
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G alpha (q) signalling events
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Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-416476:G alpha (q) signalling events
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Class C/3 (Metabotropic glutamate/pheromone receptors)
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WikiPathways
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Hypothetical Network for Drug Addiction
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GPCRs, Class C Metabotropic glutamate, pheromone
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Gastrin-CREB signalling pathway via PKC and MAPK
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GPCR ligand binding
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GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
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GPCR downstream signaling
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GPCRs, Other
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References |
REF 1 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. Epub 2009 Oct 9.Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. |