| Drug General Information |
| Drug ID |
D0Q6VH
|
| Former ID |
DNC013058
|
| Drug Name |
SIB-1893
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C14H13N
|
| InChI |
InChI=1S/C14H13N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-11H,1H3/b11-10+
|
| InChIKey |
SISOFUCTXZKSOQ-ZHACJKMWSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
93264, 7980596, 11056503, 14748605, 17405727, 24278718, 26752109, 39341108, 47944897, 48020080, 48244486, 50104764, 50104765, 53778277, 53790542, 57359481, 78678348, 85209303, 85788643, 90341151, 91722414, 92303402, 99355658, 103120636, 103296741, 103983725, 114156082, 117520149, 121361987, 124750290, 124886985, 132562594, 134350263, 135314104, 135651042, 135698407, 136352764, 137131725, 137132953, 138302982, 162249251, 163565125, 164848759, 172881068, 172914475, 179294106, 184595717, 241182237, 249581820
|
| Target and Pathway |
| Target(s) |
Metabotropic glutamate receptor 5 |
Target Info |
Inhibitor |
[2]
|
|---|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Gap junction
|
|
Long-term potentiation
|
|
Retrograde endocannabinoid signaling
|
|
Glutamatergic synapse
|
|
Huntington's disease
|
|
PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Metabotropic glutamate receptor group III pathway
|
|
Metabotropic glutamate receptor group I pathway
|
|
Endogenous cannabinoid signaling
|
|
Reactome
|
G alpha (q) signalling events
|
|
Class C/3 (Metabotropic glutamate/pheromone receptors)
|
|
WikiPathways
|
Hypothetical Network for Drug Addiction
|
|
GPCRs, Class C Metabotropic glutamate, pheromone
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
GPCR ligand binding
|
|
GPCR downstream signaling
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1432). |
|---|
| REF 2 | Bioorg Med Chem Lett. 2006 Jul 1;16(13):3371-5. Epub 2006 May 5.Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists. |
|---|
