Drug General Information
Drug ID
D0O4BC
Former ID
DNC003833
Drug Name
3-(2-Benzylamino-ethoxy)-phenol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534787]
Structure
Download
2D MOL

3D MOL

Formula
C15H17NO2
Canonical SMILES
C1=CC=C(C=C1)CNCCOC2=CC=CC(=C2)O
InChI
1S/C15H17NO2/c17-14-7-4-8-15(11-14)18-10-9-16-12-13-5-2-1-3-6-13/h1-8,11,16-17H,9-10,12H2
InChIKey
VBTFJGYCISLKEQ-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) D(3) dopamine receptor Target Info Inhibitor [525599]
D(2) dopamine receptor Target Info Inhibitor [525599]
D(4) dopamine receptor Target Info Inhibitor [525599]
5-hydroxytryptamine 1A receptor Target Info Inhibitor [534787]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04015:Rap1 signaling pathway
cAMP signaling pathway
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholismhsa04080:Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction
GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
References
Ref 534787Bioorg Med Chem Lett. 1998 Feb 3;8(3):295-300.New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates.
Ref 525599Bioorg Med Chem Lett. 1999 Sep 6;9(17):2593-8.New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template.
Ref 534787Bioorg Med Chem Lett. 1998 Feb 3;8(3):295-300.New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates.

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