Drug Information

Drug General Information
Drug ID
D0O3OS
Former ID
DNC001371
Drug Name
SR141716A
Drug Type
Small molecular drug
Indication Obesity [ICD9: 278; ICD10:E66] Approved [546366], [551871]
Structure
Download
2D MOL

3D MOL
Formula
C22H21Cl3N4O
Canonical SMILES
CC1=C(N(N=C1C(=O)NN2CCCCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(<br />C=C4)Cl
InChI
1S/C22H21Cl3N4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)
InChIKey
JZCPYUJPEARBJL-UHFFFAOYSA-N
CAS Number
CAS 158681-13-1
PubChem Compound ID
104850
PubChem Substance ID
10233641, 10587968, 12014928, 14809274, 17395319, 26757994, 44434444, 47207392, 49689350, 50029120, 53787104, 56365488, 57299045, 57337879, 68530732, 75561655, 81041153, 85209313, 91615920, 92714061, 94569195, 99443236, 103178666, 103856306, 104373082, 113635232, 117886272, 125333755, 126592979, 126629680, 126655698, 126670698, 127344006, 127344007, 127344008, 128348432, 131301471, 131549355, 134337619, 134339398, 134340563, 135135276, 135650901, 135684000, 135697615, 136375412, 137001352, 137202776, 141966451, 144205753
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Antagonist [535198], [535946]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 546366Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007737)
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535198Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide. Eur J Pharmacol. 2001 May 11;419(2-3):191-8.
Ref 535946The endogenous cannabinoid system protects against colonic inflammation. J Clin Invest. 2004 Apr;113(8):1202-9.

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