Drug Information
Drug General Information | |||||
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Drug ID |
D0O1PM
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Former ID |
DNC004003
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Drug Name |
(4-Ethynyl-cyclohex-3-enyl)-dipropyl-amine
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Synonyms |
4-ethynyl-N,N-dipropylcyclohex-3-enamine
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Indication | Discovery agent | Investigative | [525701] | ||
Structure |
Download2D MOL |
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Canonical SMILES |
CCCN(CCC)C1CCC(=CC1)C#C
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InChI |
1S/C14H23N/c1-4-11-15(12-5-2)14-9-7-13(6-3)8-10-14/h3,7,14H,4-5,8-12H2,1-2H3
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InChIKey |
IOUKEEFTYOZOKJ-UHFFFAOYSA-N
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Target and Pathway | |||||
Target(s) | D(3) dopamine receptor | Target Info | Inhibitor | [529734] | |
D(2) dopamine receptor | Target Info | Inhibitor | [525701] | ||
D(4) dopamine receptor | Target Info | Inhibitor | [525701] | ||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
Dopamine receptor mediated signaling pathway | |||||
Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
Nicotine pharmacodynamics pathway | |||||
WikiPathways | Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
Nicotine Activity on Dopaminergic Neurons | |||||
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction | |||||
Genes and (Common) Pathways Underlying Drug Addiction | |||||
Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction | |||||
GPCRs, Other | |||||
References | |||||
Ref 525701 | J Med Chem. 2000 Feb 24;43(4):756-62.Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonists recognizing preferentially the D(3) subtype. | ||||
Ref 529734 | J Med Chem. 2008 Nov 13;51(21):6829-38. Epub 2008 Oct 4.Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies. |
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