Drug Information
Drug General Information | |||||
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Drug ID |
D0O0LS
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Former ID |
DIB008673
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Drug Name |
RXDX 101
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Drug Type |
Small molecular drug
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Indication | Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] | Phase 1/2 | [532994] | ||
Company |
Ignyta
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Structure |
Download2D MOL |
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Formula |
C31H34F2N6O2
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InChI |
InChI=1S/C31H34F2N6O2/c1-38-8-10-39(11-9-38)25-3-4-26(29(19-25)34-24-6-12-41-13-7-24)31(40)35-30-27-17-20(2-5-28(27)36-37-30)14-21-15-22(32)18-23(33)16-21/h2-5,15-19,24,34H,6-14H2,1H3,(H2,35,36,37,40)
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InChIKey |
HAYYBYPASCDWEQ-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | ROS1 | Target Info | Inhibitor | [532994] | |
ALK tyrosine kinase receptor | Target Info | Inhibitor | [532994] | ||
BDNF/NT-3 growth factors receptor | Target Info | Inhibitor | [543504] | ||
Trk receptor | Target Info | Inhibitor | [532994] | ||
Neurotrophic tyrosine kinase receptor 1 | Target Info | Inhibitor | [543043] | ||
KEGG Pathway | Non-small cell lung cancerhsa04010:MAPK signaling pathway | ||||
Neurotrophin signaling pathway | |||||
Alcoholismhsa04010:MAPK signaling pathway | |||||
Endocytosis | |||||
Apoptosis | |||||
Inflammatory mediator regulation of TRP channels | |||||
Pathways in cancer | |||||
Transcriptional misregulation in cancer | |||||
Thyroid cancer | |||||
Central carbon metabolism in cancer | |||||
NetPath Pathway | IL2 Signaling Pathway | ||||
WikiPathways | Spinal Cord InjuryWP2848:Differentiation PathwayWP706:SIDS Susceptibility Pathways | ||||
BDNF signaling pathwayWP382:MAPK Signaling Pathway | |||||
BDNF signaling pathway | |||||
Integrated Pancreatic Cancer Pathway | |||||
NGF signalling via TRKA from the plasma membraneWP382:MAPK Signaling Pathway | |||||
NGF signalling via TRKA from the plasma membrane | |||||
References | |||||
Ref 532994 | ALK inhibitors in non-small cell lung cancer: crizotinib and beyond. Clin Adv Hematol Oncol. 2014 Jul;12(7):429-39. | ||||
Ref 543043 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8290). | ||||
Ref 543504 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1818). |
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