| Drug General Information |
| Drug ID |
D0N0GX
|
| Former ID |
DNC014539
|
| Drug Name |
(E)-4-(2-(thiophen-3-yl)vinyl)benzenesulfonamide
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C12H11NO2S2
|
| Canonical SMILES |
C1=CC(=CC=C1C=CC2=CSC=C2)S(=O)(=O)N
|
| InChI |
1S/C12H11NO2S2/c13-17(14,15)12-5-3-10(4-6-12)1-2-11-7-8-16-9-11/h1-9H,(H2,13,14,15)/b2-1+
|
| InChIKey |
JQHQATMSMAURMY-OWOJBTEDSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Prostaglandin G/H synthase 2 |
Target Info |
Inhibitor |
[1]
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|---|
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BioCyc Pathway
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Aspirin-triggered lipoxin biosynthesis
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Aspirin triggered resolvin D biosynthesis
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C20 prostanoid biosynthesis
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Aspirin triggered resolvin E biosynthesis
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KEGG Pathway
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Arachidonic acid metabolism
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Metabolic pathways
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NF-kappa B signaling pathway
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VEGF signaling pathway
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TNF signaling pathway
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Retrograde endocannabinoid signaling
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Serotonergic synapse
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Ovarian steroidogenesis
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Oxytocin signaling pathway
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Regulation of lipolysis in adipocytes
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Leishmaniasis
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Pathways in cancer
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Chemical carcinogenesis
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MicroRNAs in cancer
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Small cell lung cancer
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NetPath Pathway
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IL1 Signaling Pathway
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TSH Signaling Pathway
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IL4 Signaling Pathway
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TGF_beta_Receptor Signaling Pathway
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IL5 Signaling Pathway
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PANTHER Pathway
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Endothelin signaling pathway
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Inflammation mediated by chemokine and cytokine signaling pathway
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Toll receptor signaling pathway
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CCKR signaling map ST
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Pathway Interaction Database
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Calcineurin-regulated NFAT-dependent transcription in lymphocytes
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S1P1 pathway
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C-MYB transcription factor network
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Signaling mediated by p38-alpha and p38-beta
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Calcium signaling in the CD4+ TCR pathway
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PathWhiz Pathway
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Arachidonic Acid Metabolism
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WikiPathways
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Prostaglandin Synthesis and Regulation
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Arachidonic acid metabolism
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Aryl Hydrocarbon Receptor
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Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
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Spinal Cord Injury
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Integrated Pancreatic Cancer Pathway
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Eicosanoid Synthesis
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Selenium Micronutrient Network
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| References |
| REF 1 | Bioorg Med Chem Lett. 2010 Dec 1;20(23):6938-41. Epub 2010 Oct 20.Sulfonamide derivatives of styrylheterocycles as a potent inhibitor of COX-2-mediated prostaglandin E2 production. |
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