Drug General Information
Drug ID	D0MP7Z
Former ID	DNC013155
Drug Name	Dmt-Pro-Phe-D-2-Nal-NH2
Indication	Discovery agent		Investigative	[528646]
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Mu-type opioid receptor	Target Info	Inhibitor	[528646]
	Delta-type opioid receptor	Target Info	Inhibitor	[528646]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Estrogen signaling pathway
	Morphine addictionhsa04022:cGMP-PKG signaling pathway
	Sphingolipid signaling pathway
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Enkephalin releaseP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Enkephalin release
	Opioid proenkephalin pathway
	Opioid proopiomelanocortin pathway
Pathway Interaction Database	IL4-mediated signaling events
Reactome	Peptide ligand-binding receptors
	G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
	G alpha (i) signalling events
WikiPathways	TCR Signaling Pathway
	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	Opioid Signalling
	GPCR ligand binding
	GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
	GPCR downstream signaling
References
Ref 528646	J Med Chem. 2007 Feb 8;50(3):512-20.Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D-2-Nal(4)]endomorphin-2 (Antanal-2).
Ref 528646	J Med Chem. 2007 Feb 8;50(3):512-20.Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D-2-Nal(4)]endomorphin-2 (Antanal-2).

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