Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0M5HY
|
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| Former ID |
DIB019100
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| Drug Name |
CDPPB
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C23H16N4O
|
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| InChI |
InChI=1S/C23H16N4O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20/h1-15H,(H,25,28)
|
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| InChIKey |
BKUIZWILNWHFHD-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
16330111, 23423727, 26759128, 42325007, 53788196, 53800679, 56310618, 57376329, 77736367, 93580910, 103458993, 104043351, 123044929, 123392804, 125654101, 126582271, 126634558, 126739012, 134348493, 135343993, 135650062, 135698868, 137007772, 137249726, 139466067, 162220792, 162913781, 163687721, 163781184, 201507959, 204366790, 208264896, 208265549, 227996902, 241376330, 244698141, 252157115
|
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| Target and Pathway | |||||
| Target(s) | Metabotropic glutamate receptor 5 | Target Info | Modulator (allosteric modulator) | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Long-term potentiation | |||||
| Retrograde endocannabinoid signaling | |||||
| Glutamatergic synapse | |||||
| Huntington's disease | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Metabotropic glutamate receptor group III pathway | |||||
| Metabotropic glutamate receptor group I pathway | |||||
| Endogenous cannabinoid signaling | |||||
| Reactome | G alpha (q) signalling events | ||||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |||||
| WikiPathways | Hypothetical Network for Drug Addiction | ||||
| GPCRs, Class C Metabotropic glutamate, pheromone | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1422). | ||||
| REF 2 | Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo. JMed Chem. 2004 Nov 18;47(24):5825-8. | ||||
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