Drug Information

Drug General Information
Drug ID
D0M2YE
Former ID
DNAP001412
Drug Name
Lanreotide acetate
Synonyms
Somatuline lp (TN)
Drug Type
Small molecular drug
Indication Acromegaly [ICD9: 253; ICD10:E22.0] Approved [532253], [539302]
Company
Beaufour-Ipsen
Structure
Download
2D MOL

3D MOL
Formula
C54H69N11O10S2
InChI
InChI=1S/C54H69N11O10S2/c1-29(2)45-54(75)63-44(53(74)65-46(30(3)66)47(57)68)28-77-76-27-43(62-48(69)38(56)23-32-15-18-33-10-4-5-11-34(33)22-32)52(73)60-41(24-31-16-19-36(67)20-17-31)50(71)61-42(25-35-26-58-39-13-7-6-12-37(35)39)51(72)59-40(49(70)64-45)14-8-9-21-55/h4-7,10-13,15-20,22,26,29-30,38,40-46,58,66-67H,8-9,14,21,23-25,27-28,55-56H2,1-3H3,(H2,57,68)(H,59,72)(H,60,73)(H,61,71)(H,62,69)(H,63,75)(H,64,70)(H,65,74)
InChIKey
PUDHBTGHUJUUFI-UHFFFAOYSA-N
PubChem Compound ID
71349
PubChem Substance ID
4486252, 24897906, 43127689, 50054674, 50064235, 50125916, 50173040, 57318148, 85209139, 104350246, 125672970, 126682874, 127320088, 127320089, 127320090, 127320091, 127320092, 127320093, 127320094, 127320095, 127320096, 127320097, 127320098, 127320099, 127320100, 134222134, 134338678, 135029361, 135652022, 136101008, 137249412, 162224768, 163142465, 179294123, 223654400, 226420612, 239773461, 251971062
SuperDrug ATC ID
H01CB03
Target and Pathway
Target(s) Somatostatin receptor type 2 Target Info Modulator [532253]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways SIDS Susceptibility Pathways
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 532253Pasireotide, a multi-somatostatin receptor ligand with potential efficacy for treatment of pituitary and neuroendocrine tumors. Drugs Today (Barc). 2013 Feb;49(2):89-103.
Ref 539302(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2031).
Ref 532253Pasireotide, a multi-somatostatin receptor ligand with potential efficacy for treatment of pituitary and neuroendocrine tumors. Drugs Today (Barc). 2013 Feb;49(2):89-103.

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