Drug Information

Drug General Information
Drug ID
D0M1EI
Former ID
DNC014349
Drug Name
5-(2-Methylquinolin-7-yl)-2-phenylbenzonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530843]
Structure
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2D MOL

3D MOL
Formula
C23H16N2
Canonical SMILES
CC1=NC2=C(C=C1)C=CC(=C2)C3=CC(=C(C=C3)C4=CC=CC=C4)C#N
InChI
1S/C23H16N2/c1-16-7-8-18-9-10-20(14-23(18)25-16)19-11-12-22(21(13-19)15-24)17-5-3-2-4-6-17/h2-14H,1H3
InChIKey
AGKCPUQJKJZENU-UHFFFAOYSA-N
PubChem Compound ID
46888045
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [530843]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 530843Bioorg Med Chem. 2010 May 1;18(9):3026-35. Epub 2010 Mar 27.Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5.
Ref 530843Bioorg Med Chem. 2010 May 1;18(9):3026-35. Epub 2010 Mar 27.Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5.

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