Drug Information

Drug General Information
Drug ID
D0M1AE
Former ID
DNC007122
Drug Name
N-{4-[(benzylamino)sulfonyl]-1-naphthyl}benzamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528647]
Structure
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2D MOL

3D MOL
Formula
C24H20N2O3S
Canonical SMILES
C1=CC=C(C=C1)CNS(=O)(=O)C2=CC=C(C3=CC=CC=C32)NC(=O)C4=C<br />C=CC=C4
InChI
1S/C24H20N2O3S/c27-24(19-11-5-2-6-12-19)26-22-15-16-23(21-14-8-7-13-20(21)22)30(28,29)25-17-18-9-3-1-4-10-18/h1-16,25H,17H2,(H,26,27)
InChIKey
QPJKMKVTEJYYGG-UHFFFAOYSA-N
PubChem Compound ID
11270007
Target and Pathway
Target(s) C-C chemokine receptor type 8 Target Info Inhibitor [528647]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Viral carcinogenesis
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 528647J Med Chem. 2007 Feb 8;50(3):566-84.Design, synthesis, and evaluation of naphthalene-sulfonamide antagonists of human CCR8.
Ref 528647J Med Chem. 2007 Feb 8;50(3):566-84.Design, synthesis, and evaluation of naphthalene-sulfonamide antagonists of human CCR8.

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