Drug General Information
Drug ID	D0L1PQ
Former ID	DNC004988
Drug Name	3-(3-Pyridin-2-yl-pyrrol-1-yl)-benzonitrile
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527190]
Structure		Download 2D MOL 3D MOL
Formula	C16H11N3
Canonical SMILES	C1=CC=NC(=C1)C2=CN(C=C2)C3=CC=CC(=C3)C#N
InChI	1S/C16H11N3/c17-11-13-4-3-5-15(10-13)19-9-7-14(12-19)16-6-1-2-8-18-16/h1-10,12H
InChIKey	VWIHRRSEESXDSS-UHFFFAOYSA-N
PubChem Compound ID	10332109
Target and Pathway
Target(s)	Metabotropic glutamate receptor 5	Target Info	Inhibitor	[527190]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Huntington's disease
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 527190	J Med Chem. 2004 Sep 9;47(19):4645-8.Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity.
Ref 527190	J Med Chem. 2004 Sep 9;47(19):4645-8.Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity.

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