Drug General Information
Drug ID
D0K7IW
Former ID
DIB019207
Drug Name
compound 11d
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542990], [552148]
Formula
C23H25N3O5
InChI
InChI=1S/C23H25N3O5/c1-29-19-4-6-21-16(10-19)9-17(14-31-21)23(28)26-20-5-3-15(18-12-24-25-13-18)11-22(20)30-8-2-7-27/h3-6,10-13,17,27H,2,7-9,14H2,1H3,(H,24,25)(H,26,28)/t17-/m0/s1
InChIKey
YHIPVWFQESXDIE-KRWDZBQOSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Rho associated protein kinase 2 Target Info Inhibitor [543434]
CDC42 binding protein kinase alpha (DMPK-like) Target Info Inhibitor [543436]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
Sphingolipid signaling pathway
Vascular smooth muscle contraction
Wnt signaling pathway
Axon guidance
Focal adhesion
Platelet activation
Leukocyte transendothelial migration
Regulation of actin cytoskeleton
Oxytocin signaling pathway
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Pathways in cancer
Proteoglycans in cancer
PANTHER Pathway Cytoskeletal regulation by Rho GTPase
Pathway Interaction Database RhoA signaling pathway
Plasma membrane estrogen receptor signaling
Osteopontin-mediated events
PLK1 signaling events
PAR4-mediated thrombin signaling events
PAR1-mediated thrombin signaling events
Signaling events mediated by focal adhesion kinase
Reactome EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
VEGFA-VEGFR2 Pathway
RHO GTPases Activate ROCKs
WikiPathways G13 Signaling Pathway
Regulation of Actin Cytoskeleton
Focal Adhesion
JAK/STAT
Spinal Cord Injury
Pathogenic Escherichia coli infection
Leptin signaling pathway
Semaphorin interactions
Integrin-mediated Cell Adhesion
GPCR downstream signaling
MicroRNAs in cardiomyocyte hypertrophy
Androgen receptor signaling pathway
References
Ref 542990(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8197).
Ref 552148Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors. Med. Chem. Commun., 2011,2, 73-75.
Ref 543434(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1504).
Ref 543436(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1507).

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