Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0K0ZK
|
||||
| Former ID |
DIB003556
|
||||
| Drug Name |
ADX-63365
|
||||
| Synonyms |
MGluR5 PAM; ADX-4; ADX-47273; ADX-50938; MGluR5 positive modulators, Addex; ADX-4 program, Addex
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Central nervous system disease [ICD10:G00-G99] | Investigative | [1] | ||
| Company |
Addex Pharmaceuticals SA
|
||||
| Structure |
|
Download2D MOL |
|||
| Formula |
C20H17F2N3O2
|
||||
| InChI |
InChI=1S/C20H17F2N3O2/c21-16-7-3-13(4-8-16)18-23-19(27-24-18)15-2-1-11-25(12-15)20(26)14-5-9-17(22)10-6-14/h3-10,15H,1-2,11-12H2/t15-/m0/s1
|
||||
| InChIKey |
VXQCCZHCFBHTTD-HNNXBMFYSA-N
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID |
16477027, 23536103, 42462271, 75375724, 99431602, 103489132, 104071520, 135649898, 135693358, 135723349, 136348852, 136946586, 141239375, 144115548, 144240227, 162011599, 162202778, 162219991, 172650451, 174007047, 174530985, 186009058, 189561517, 198977704, 226552698, 242585865, 244602588, 252110345, 252450460
|
||||
| Target and Pathway | |||||
| Target(s) | Metabotropic glutamate receptor 5 | Target Info | Modulator | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Long-term potentiation | |||||
| Retrograde endocannabinoid signaling | |||||
| Glutamatergic synapse | |||||
| Huntington's disease | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Metabotropic glutamate receptor group III pathway | |||||
| Metabotropic glutamate receptor group I pathway | |||||
| Endogenous cannabinoid signaling | |||||
| Reactome | G alpha (q) signalling events | ||||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |||||
| WikiPathways | Hypothetical Network for Drug Addiction | ||||
| GPCRs, Class C Metabotropic glutamate, pheromone | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1420). | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 293). | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.