Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0I8FI
|
||||
| Former ID |
DAP000080
|
||||
| Drug Name |
Isoproterenol
|
||||
| Synonyms |
Aerolone; Aleudrine; Aludrin; Aludrine; Asiprenol; Asmalar; Assiprenol; Bellasthman; Bronkephrine; Dihydroxyphenylethanolisopropylamine; Euspiran; ISOPROP; Isadrin; Isadrine; Isonorene; Isonorin; Isoprenalin; Isoprenaline; Isopropydrin; Isopropyladrenaline; Isopropylarterenol; Isopropylnoradrenaline; Isopropylnorepinephrine; Isoproterenolum; Isorenin; Isuprel; Isupren; Izadrin; Lomupren; Neodrenal; Norisodrine; Novodrin; Proternol; Respifral; Saventrine; Epinephrine isopropyl homolog; Isoprenaline hydrochloride; Isopropyl noradrenaline; Isoproterenol Chloride; Isoproterenol [JAN]; Isuprel Mistometer; Racemic isoprenaline; Racemic isoproterenol; WIN 5162; D-Isoprenaline; D-Isopropylarterenol; D-Isoproterenol; DL-Isopropylnorepinephrine; Dl-Ipr; Dl-Isadrine; Dl-Isopropylnoradrenaline; Isoprenalina [INN-Spanish]; Isoprenaline (INN); Isoprenalinum [INN-Latin]; Isuprel (TN); L-Isopropylnoradrenaline; L-Isoproterenol; Medihaler-ISO; N-Isopropylnoradrenaline; N-Isopropylnorepinephrine; Neo-Epinine; Vapo-Iso; Alpha-(Isopropylaminomethyl)protocatechuyl alcohol; Alpha-(Isopropylaminomoethyl)protocatechuyl alcohol; D-N-Isopropylnorepinephrine; Dl-N-Isopropylnoradrenaline; Vapo-N-iso; Isopropylaminomethyl(3,4-dihydroxyphenyl)carbinol; Isopropylaminomethyl-3,4-dihydroxyphenyl carbinol; DL(+-)-Isoproterenol; N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine; (+)-Isoprenaline; (+)-Isoproterenol; (+-)-Isoprenaline; (+-)-Isoproterenol; (-)-Isoproterenol hydrochloride; (S)-(+)-Isoproterenol; (S)-Isoprenaline; (S)-Isoproterenol; 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-(9CI); 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, (S)-(9CI); 1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol; 1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol; 3,4-Dihydroxy-.alpha.-(isopropylaminomethyl)-benzyl alcohol; 3,4-Dihydroxy-.alpha.-[(isopropylamino)methyl]benzyl alcohol; 3,4-Dihydroxy-alpha-((isopropylamino)methyl)benzyl alcohol; 4-(1-Hydroxy-2(isopropylamino)ethyl)-benzene 1,2-diol; 4-(1-Hydroxy-2-((1-methylethyl)amino)ethyl)-1,2-benzenediol; 4-{1-hydroxy-2-[(1-methylethyl)amino]ethyl}benzene-1,2-diol
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Bradycardia; Heart block [ICD9: 116.0, 426.9; ICD10:B40, I44-I45] | Approved | [1] | ||
| Therapeutic Class |
Cardiotonic Agents
|
||||
| Company |
Abbott Laboratories
|
||||
| Structure |
|
Download2D MOL |
|||
| Formula |
C11H17NO3
|
||||
| Canonical SMILES |
CC(C)NCC(C1=CC(=C(C=C1)O)O)O
|
||||
| InChI |
1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3
|
||||
| InChIKey |
JWZZKOKVBUJMES-UHFFFAOYSA-N
|
||||
| CAS Number |
CAS 7683-59-2
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID |
9268, 75322, 91788, 611308, 3133594, 5272313, 8152391, 10535368, 11336069, 11361308, 11363843, 11366405, 11368967, 11371528, 11373566, 11377129, 11462280, 11467125, 11468245, 11484778, 11486793, 11488877, 11490290, 11491839, 11494763, 11534308, 14748912, 24430805, 24715029, 26512260, 26752240, 29222898, 46507323, 47216837, 47291195, 47365254, 47440329, 47515375, 47810812, 47959817, 48334566, 48416134, 49892804, 49892806, 49892807, 50104946, 50111114, 53790889, 56313305, 56313643
|
||||
| ChEBI ID |
ChEBI:6046
|
||||
| SuperDrug ATC ID |
C01CA02; R03AB02; R03CB01
|
||||
| SuperDrug CAS ID |
cas=007683592
|
||||
| Target and Pathway | |||||
| Target(s) | Beta-2 adrenergic receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cGMP-PKG signaling pathway | |||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Endocytosis | |||||
| Adrenergic signaling in cardiomyocytes | |||||
| Salivary secretion | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Beta2 adrenergic receptor signaling pathway | |||||
| Pathway Interaction Database | Arf6 trafficking events | ||||
| Arf6 signaling events | |||||
| Reactome | Adrenoceptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| Calcium Regulation in the Cardiac Cell | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Vitamin D Receptor Pathway | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 083346. | ||||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.