Drug General Information
Drug ID	D0I4VT
Former ID	DNC012089
Drug Name	1-Propyl-3-(3-trifluoromethyl-phenyl)-pyrrolidine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[551334]
Structure		Download 2D MOL 3D MOL
Formula	C14H18F3N
Canonical SMILES	CCCN1CCC(C1)C2=CC(=CC=C2)C(F)(F)F
InChI	1S/C14H18F3N/c1-2-7-18-8-6-12(10-18)11-4-3-5-13(9-11)14(15,16)17/h3-5,9,12H,2,6-8,10H2,1H3
InChIKey	YATKXAPVZGTXAR-UHFFFAOYSA-N
PubChem Compound ID	44460502
Target and Pathway
Target(s)	D(2) dopamine receptor	Target Info	Inhibitor	[551334]
	5-hydroxytryptamine 1A receptor	Target Info	Inhibitor	[551334]
	5-hydroxytryptamine 2A receptor	Target Info	Inhibitor	[551334]
	D(3) dopamine receptor	Target Info	Inhibitor	[551334]
KEGG Pathway	Rap1 signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Alcoholismhsa04024:cAMP signaling pathway
	Serotonergic synapsehsa04020:Calcium signaling pathway
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channelshsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome	Dopamine receptors
	G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (q) signalling eventsR-HSA-390651:Dopamine receptors
	G alpha (i) signalling events
WikiPathways	Hypothetical Network for Drug Addiction
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Genes and (Common) Pathways Underlying Drug Addiction
	GPCR ligand binding
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic NeuronsWP722:Serotonin HTR1 Group and FOS Pathway
	SIDS Susceptibility Pathways
	GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCRs, OtherWP58:Monoamine GPCRs
	Nicotine Activity on Dopaminergic Neurons
	GPCRs, Other
References
Ref 551334	Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity, Bioorg. Med. Chem. Lett. 7(3):241-246 (1997).
Ref 551334	Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity, Bioorg. Med. Chem. Lett. 7(3):241-246 (1997).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.