Drug Information

Drug General Information
Drug ID
D0HI1K
Former ID
DCL000384
Drug Name
GSK618334
Drug Type
Small molecular drug
Indication Drug abuse [ICD9: 303-304; ICD10:F10-F19] Phase 1 [522083]
Company
GSK
Structure
Download
2D MOL

3D MOL
Formula
C19H34ClNO2
Canonical SMILES
CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl
InChI
1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H
InChIKey
SWZTYAVBMYWFGS-UHFFFAOYSA-N
CAS Number
CAS 162359-56-0
PubChem Compound ID
107969
PubChem Substance ID
10234529, 12014880, 14900483, 26758737, 44436887, 47206133, 50021117, 53600034, 53800768, 57338355, 85171085, 92719820, 98528441, 99300584, 99436939, 103669455, 104380162, 109692984, 117672600, 118842531, 124757869, 124772071, 125164672, 125342329, 126522748, 126628080, 126648547, 126666984, 126731322, 134339028, 134339285, 134964386, 135066165, 135727426, 136345852, 136367507, 136367937, 136920394, 136964585, 137065890, 143493393, 144115996, 152233650, 152258330, 160647169, 162011674, 162037993, 162185346, 163378868, 163688106
Target and Pathway
Target(s) D(3) dopamine receptor Target Info Antagonist [550963]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapse
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, Other
References
Ref 522083ClinicalTrials.gov (NCT00513279) To Investigate If Single Doses Of GSK618334 Are Safe And To Investigate Blood Levels Of GSK618334. U.S. National Institutes of Health.
Ref 550963Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

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