Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0F9QY
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| Former ID |
DIB018579
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| Drug Name |
3,3'-difluorobenzaldazine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C14H10F2N2
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| InChI |
InChI=1S/C14H10F2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H/b17-9+,18-10+
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| InChIKey |
YYMCVDNIIFNDJK-BEQMOXJMSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
24640122, 43224630, 50104919, 50104920, 75885289, 85787621, 90341252, 91703710, 96052388, 103458889, 104043354, 114638185, 121361631, 124887046, 135698435, 144240231, 162248416, 163781288, 164821009, 175612575, 179335167, 184557883, 189353164, 206247677, 237140121, 237559857, 241182585, 241375544, 252365683
|
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| Target and Pathway | |||||
| Target(s) | Metabotropic glutamate receptor 5 | Target Info | Modulator (allosteric modulator) | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Long-term potentiation | |||||
| Retrograde endocannabinoid signaling | |||||
| Glutamatergic synapse | |||||
| Huntington's disease | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Metabotropic glutamate receptor group III pathway | |||||
| Metabotropic glutamate receptor group I pathway | |||||
| Endogenous cannabinoid signaling | |||||
| Reactome | G alpha (q) signalling events | ||||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |||||
| WikiPathways | Hypothetical Network for Drug Addiction | ||||
| GPCRs, Class C Metabotropic glutamate, pheromone | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1424). | ||||
| REF 2 | A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol. 2003 Sep;64(3):731-40. | ||||
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