Drug General Information
Drug ID	D0EK6F
Former ID	DNC007537
Drug Name	5-methyl-3-phenylethynyl[1,2,4]triazine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528893]
Structure		Download 2D MOL 3D MOL
Formula	C12H9N3
Canonical SMILES	CC1=CN=NC(=N1)C#CC2=CC=CC=C2
InChI	1S/C12H9N3/c1-10-9-13-15-12(14-10)8-7-11-5-3-2-4-6-11/h2-6,9H,1H3
InChIKey	PXUGAXNBWJVVQY-UHFFFAOYSA-N
PubChem Compound ID	16736030
Target and Pathway
Target(s)	Metabotropic glutamate receptor 5	Target Info	Inhibitor	[528893]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Huntington's disease
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 528893	J Med Chem. 2007 Jul 12;50(14):3388-91. Epub 2007 Jun 15.Synthesis and pharmacological evaluation of phenylethynyl[1,2,4]methyltriazines as analogues of 3-methyl-6-(phenylethynyl)pyridine.
Ref 528893	J Med Chem. 2007 Jul 12;50(14):3388-91. Epub 2007 Jun 15.Synthesis and pharmacological evaluation of phenylethynyl[1,2,4]methyltriazines as analogues of 3-methyl-6-(phenylethynyl)pyridine.

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