Drug Information

Drug General Information
Drug ID
D0E9VU
Former ID
DNC012645
Drug Name
LEVONORDEFRIN
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468149]
Structure
Download
2D MOL

3D MOL
Formula
C9H13NO3
InChI
InChI=1S/C9H13NO3/c1-5(10)9(13)6-2-3-7(11)8(12)4-6/h2-5,9,11-13H,10H2,1H3/t5-,9-/m0/s1
InChIKey
GEFQWZLICWMTKF-CDUCUWFYSA-N
CAS Number
CAS 829-74-3
PubChem Compound ID
164739
PubChem Substance ID
13932, 7849447, 8149401, 10255593, 11111073, 11112447, 11335490, 11360729, 11364536, 11367098, 11369660, 11371540, 11373602, 11377822, 11461701, 11484746, 11488871, 11490296, 11491847, 11495456, 15947283, 24277784, 26611796, 26679431, 46238888, 47216686, 47365101, 47885314, 48110365, 48334396, 48334397, 48479897, 49699157, 50065272, 50100443, 50100444, 57350546, 57654107, 79290449, 92124111, 92307503, 99301403, 99443259, 103190505, 103938162, 113454748, 121363335, 124550756, 124637940, 124882389
Target and Pathway
Target(s) Alpha-1D adrenergic receptor Target Info Inhibitor [534160]
Alpha-1B adrenergic receptor Target Info Inhibitor [534160]
Alpha-1A adrenergic receptor Target Info Inhibitor [534160]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04020:Calcium signaling pathway
AMPK signaling pathway
Salivary secretion
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Pathway Interaction Database LPA receptor mediated events
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
Vitamin D Receptor Pathway
AMPK SignalingWP58:Monoamine GPCRs
Endothelin Pathways
AMPK Signaling
References
Ref 468149(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 508).
Ref 534160J Med Chem. 1996 Jul 19;39(15):3001-13.Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene derivatives of medetomidine.

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