| Drug General Information |
| Drug ID |
D0A9ED
|
| Former ID |
DNC000387
|
| Drug Name |
Carazolol
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C18H22N2O2
|
| InChI |
InChI=1S/C18H22N2O2/c1-12(2)19-10-13(21)11-22-17-9-5-8-16-18(17)14-6-3-4-7-15(14)20-16/h3-9,12-13,19-21H,10-11H2,1-2H3
|
| InChIKey |
BQXQGZPYHWWCEB-UHFFFAOYSA-N
|
| CAS Number |
CAS 51997-43-4
|
| PubChem Compound ID |
|
| PubChem Substance ID |
6685022, 7978853, 8194800, 15468496, 43128022, 50022846, 51091918, 57318337, 79557571, 85208998, 91611495, 103089481, 103153519, 103331481, 103937132, 104351190, 117613301, 126671688, 127555400, 134339829, 135029386, 135650054, 136161295, 137024393, 137251459, 162185417, 162251286, 162863557, 164786782, 172089152, 179150703, 184545382, 206246514, 223674687, 223704591, 226457254, 226457255, 250061443, 251890234, 252359210, 252390123
|
| Target and Pathway |
| Target(s) |
Beta-1 adrenergic receptor |
Target Info |
Agonist |
[2]
|
|---|
| Beta-3 adrenergic receptor |
Target Info |
Agonist |
[2]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
cGMP-PKG signaling pathway
|
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Endocytosis
|
|
Adrenergic signaling in cardiomyocytes
|
|
Gap junction
|
|
Salivary secretion
|
|
Dilated cardiomyopathyhsa04020:Calcium signaling pathway
|
|
PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Beta1 adrenergic receptor signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Beta3 adrenergic receptor signaling pathway
|
|
PathWhiz Pathway
|
Muscle/Heart Contraction
|
|
Reactome
|
Adrenoceptors
|
|
G alpha (s) signalling eventsR-HSA-390696:Adrenoceptors
|
|
G alpha (s) signalling events
|
|
WikiPathways
|
Monoamine GPCRs
|
|
Calcium Regulation in the Cardiac Cell
|
|
GPCRs, Class A Rhodopsin-like
|
|
Endothelin Pathways
|
|
GPCR ligand binding
|
|
GPCR downstream signalingWP58:Monoamine GPCRs
|
|
GPCR downstream signaling
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 569). |
|---|
| REF 2 | Current therapeutic uses and potential of beta-adrenoceptor agonists and antagonists. Eur J Clin Pharmacol. 1998 Feb;53(6):389-404. |
|---|
