Drug General Information
Drug ID	D09RPR
Former ID	DIB020969
Drug Name	SP203
Synonyms	SP 203; SP-203
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541574]
Structure		Download 2D MOL
Formula	C13H6F2N2S
InChI	InChI=1S/C13H6F2N2S/c14-6-13-17-12(8-18-13)2-1-9-3-10(7-16)5-11(15)4-9/h3-5,8H,6H2
InChIKey	WTLBLIGPXACYET-UHFFFAOYSA-N
PubChem Compound ID	16737207
PubChem Substance ID	26695432, 46146451, 46570952, 103520919, 104090124, 163642981, 178103050, 198943132, 223258876, 245055473
Target and Pathway
Target(s)	Metabotropic glutamate receptor 5	Target Info	Modulator (allosteric modulator)	[528895]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Huntington's disease
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 541574	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6434).
Ref 528895	Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography. J Med Chem. 2007 Jul 12;50(14):3256-66. Epub 2007 Jun 16.

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